{"id":"W2788934158","doi":"10.1016/j.celrep.2018.01.073","title":"BK Potassium Channels Suppress Cavα2δ Subunit Function to Reduce Inflammatory and Neuropathic Pain","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Savoy Foundation","keywords":"Dorsal root ganglion; BK channel; Calcium-activated potassium channel; Protein subunit; Neuropathic pain; Potassium channel; Neurotransmission; Cell biology; Downregulation and upregulation; Chemistry; Calcium channel; N-type calcium channel; R-type calcium channel; Extracellular; Calcium; Neuroscience; Biophysics; T-type calcium channel; Biology; Receptor; Biochemistry; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582178,0.0003030422,0.0003622852,0.0001741927,0.0001711422,0.0003671222,0.0002779205,0.0002883515,0.002401823],"category_scores_gemma":[0.0001844308,0.0001221507,0.0002070783,0.0001611719,0.0002554793,0.0003708286,0.0001707861,0.0008685965,0.000554077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372047,"about_ca_system_score_gemma":0.0002971882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003491203,"about_ca_topic_score_gemma":0.0005751032,"domain_scores_codex":[0.9998143,0.00002289976,0.00001883119,0.00003015412,0.0000467438,0.0000671456],"domain_scores_gemma":[0.9998989,0.00001395498,0.00002563824,0.00001492056,0.00001662139,0.00002996039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000215781,0.00007013533,0.0000494024,0.00002661153,0.000003170623,0.00001187994,0.000007902334,0.00004397063,0.9983559,0.0001203738,0.00004088828,0.001053852],"study_design_scores_gemma":[0.00009755517,0.0006949891,0.002042041,0.000007084175,0.00002482894,0.0001703895,0.00003352654,0.00115113,0.9931645,0.0001634906,0.002444301,0.000006189531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903902,0.001736476,0.005240747,0.0002552129,0.0001286528,0.00003788558,0.0001805747,0.0001620796,0.001868168],"genre_scores_gemma":[0.9933785,0.0009401184,0.002243488,0.00009640989,0.00002842788,0.00003647005,0.00018959,0.00005293482,0.003034187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002401823,"threshold_uncertainty_score":0.008034945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100599037961091,"score_gpt":0.2198244451501606,"score_spread":0.2097645413540515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}