{"id":"W2788965461","doi":"10.1097/cji.0000000000000216","title":"Characterization of Postinfusion Phenotypic Differences in Fresh Versus Cryopreserved TCR Engineered Adoptive Cell Therapy Products","year":2018,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"David Geffen School of Medicine, University of California, Los Angeles; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; UCLA AIDS Institute; Center for AIDS Research, University of Washington; Jonsson Comprehensive Cancer Center; Parker Institute for Cancer Immunotherapy","keywords":"Flow cytometry; Ex vivo; T cell; Immunology; T-cell receptor; Transgene; Cell therapy; Cell; Genetically modified mouse; Medicine; Biology; Cancer research; In vivo; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006403898,0.000210638,0.0005927841,0.0004955434,0.00004559497,0.00002674761,0.0003055495,0.0001297584,0.002251774],"category_scores_gemma":[0.0001089025,0.000158218,0.0001493007,0.0006166864,0.0001531543,0.0002173733,0.00002599312,0.0004096577,0.000006857358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247285,"about_ca_system_score_gemma":0.0002930719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004737712,"about_ca_topic_score_gemma":0.000008737004,"domain_scores_codex":[0.9979553,0.0001701023,0.0007429503,0.0001881527,0.000650665,0.0002927833],"domain_scores_gemma":[0.9978325,0.0001327596,0.0005343868,0.000369028,0.001051262,0.00008007159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02333303,0.0005857986,0.008955608,0.00003276443,0.0001661505,0.0000133181,0.002490983,0.000001272635,0.9451183,0.000005840983,0.00005567709,0.01924122],"study_design_scores_gemma":[0.01183887,0.005568121,0.2709592,0.0002263168,0.0000138536,0.00001779317,0.0001828958,0.00006044985,0.7092326,0.00002159807,0.001750945,0.0001273505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961296,0.001646693,0.0001267235,0.0005436402,0.0006174862,0.0005290099,0.000006546178,0.00001268728,0.0003876335],"genre_scores_gemma":[0.9928911,0.004961737,0.0006655428,0.00009178231,0.0006382172,0.000005478075,0.00001307409,0.00004506761,0.000688054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2620036,"threshold_uncertainty_score":0.9986603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03856796019210099,"score_gpt":0.2848395910190238,"score_spread":0.2462716308269229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}