{"id":"W2788965461","doi":"10.1097/cji.0000000000000216","title":"Characterization of Postinfusion Phenotypic Differences in Fresh Versus Cryopreserved TCR Engineered Adoptive Cell Therapy Products","year":2018,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"David Geffen School of Medicine, University of California, Los Angeles; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; UCLA AIDS Institute; Center for AIDS Research, University of Washington; Jonsson Comprehensive Cancer Center; Parker Institute for Cancer Immunotherapy","keywords":"Flow cytometry; Ex vivo; T cell; Immunology; T-cell receptor; Transgene; Cell therapy; Cell; Genetically modified mouse; Medicine; Biology; Cancer research; In vivo; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410721,0.0001368591,0.000152958,0.0001637624,0.00005857696,0.000314839,0.0001421219,0.0001475149,0.000552834],"category_scores_gemma":[0.0004355147,0.00007831681,0.0001101697,0.000153589,0.0001138573,0.0001620341,0.00009351001,0.0003139719,0.0001444192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000119319,"about_ca_system_score_gemma":0.00008469264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001969965,"about_ca_topic_score_gemma":0.0001632468,"domain_scores_codex":[0.9998409,0.00002578916,0.00001541313,0.00003499637,0.00005807287,0.0000248749],"domain_scores_gemma":[0.9997625,0.0000580195,0.00006459458,0.00002665904,0.00005271875,0.0000355266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004109013,0.00007317016,0.003699512,0.00001946729,0.00001036006,0.00005825977,0.0000575684,0.0002502229,0.9897317,0.00003693158,0.00004180736,0.005610009],"study_design_scores_gemma":[0.00002867646,0.002896121,0.0581177,0.000008403147,0.0000775981,0.0005461955,0.00005858915,0.002285394,0.9346231,0.00004341478,0.001306311,0.000008545626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976248,0.0002985375,0.001533801,0.0000124452,0.000006519297,0.00003183337,0.0001825278,0.00002218495,0.0002873119],"genre_scores_gemma":[0.9976222,0.0001709908,0.001285982,0.00003374298,0.000005164242,0.00005730615,0.0004156285,0.00001341696,0.0003956457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000552834,"threshold_uncertainty_score":0.001849413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03856796019210099,"score_gpt":0.2848395910190238,"score_spread":0.2462716308269229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}