{"id":"W2788984236","doi":"10.1186/s13293-018-0169-7","title":"X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells","year":2018,"lang":"en","type":"article","venue":"Biology of Sex Differences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université du Québec à Chicoutimi; Centre de Santé et de Services Sociaux de Chicoutimi; McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Testis determining factor; DNA methylation; Biology; Methylation; Epigenetics; Genetics; Molecular biology; X chromosome; Locus (genetics); Gene; Y chromosome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213289,0.0001313264,0.0001271639,0.000235703,0.000106065,0.0001901847,0.0001064498,0.0001329855,0.002706974],"category_scores_gemma":[0.0001959443,0.0001343857,0.0001160156,0.0001681809,0.0001577998,0.00008614346,0.0001687494,0.0001185116,0.0004234338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339235,"about_ca_system_score_gemma":0.0001048917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059186,"about_ca_topic_score_gemma":0.001208295,"domain_scores_codex":[0.9999088,0.00002087574,0.000006762246,0.00002969574,0.00002253104,0.00001128932],"domain_scores_gemma":[0.9998958,0.0000350823,0.00003243611,0.0000131041,0.00001312744,0.00001046952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001835992,0.000007540484,0.006215599,0.00002411627,0.00001453184,0.00006741469,0.00009531788,0.000058023,0.9901885,0.0001107629,0.00003113722,0.003003527],"study_design_scores_gemma":[0.00002203793,0.0003138319,0.2086796,0.000009656826,0.00005087026,0.001190122,0.0001815224,0.0007465993,0.7851638,0.0001941698,0.003435233,0.00001259298],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958205,0.001177873,0.001400538,0.0000283239,0.00000446194,0.000007622366,0.000364878,0.00002535713,0.001170276],"genre_scores_gemma":[0.9972171,0.0005369735,0.0006967032,0.00001421906,0.000002212479,0.00000909593,0.000328621,0.0000096531,0.001185407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002706974,"threshold_uncertainty_score":0.009055734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0342742531896672,"score_gpt":0.2776888784440169,"score_spread":0.2434146252543497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}