{"id":"W2789011244","doi":"10.1021/acschembio.8b00039","title":"Snapshots of the Catalytic Cycle of an O <sub>2</sub> , Pyridoxal Phosphate-Dependent Hydroxylase","year":2018,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Metal-Catalyzed Oxygenation Mechanisms","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alfred P. Sloan Foundation","keywords":"Cofactor; Hydroxylation; Chemistry; Catalytic cycle; Enzyme; Catalysis; Stereospecificity; Pyridoxal phosphate; Tetrahydrobiopterin; Stereochemistry; Arginine; Oxidase test; Pyridoxal; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485502,0.0002189167,0.0003827381,0.0000418291,0.00005105092,0.000006020087,0.0008358465,0.0003556338,0.0004292659],"category_scores_gemma":[0.0004008458,0.0001653504,0.000137114,0.0001874982,0.000614444,0.00007042968,0.0003574602,0.0002296342,0.0000733105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005352539,"about_ca_system_score_gemma":0.00007382857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004266134,"about_ca_topic_score_gemma":0.0000122397,"domain_scores_codex":[0.9983533,0.0000463573,0.000561598,0.0004500165,0.0002359279,0.0003527987],"domain_scores_gemma":[0.9982561,0.0001284873,0.0003646701,0.0009519255,0.0001666738,0.000132083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007295988,0.0001645693,0.0001129805,0.00004431326,0.00005698782,0.000001560249,0.00009132759,0.000001758678,0.9963098,0.0007994993,0.00005290991,0.002291365],"study_design_scores_gemma":[0.0006949882,0.0000522198,0.00002556253,0.00001731446,0.00005120909,0.00002076965,0.00003730937,0.0001997374,0.9945474,0.004084962,0.00009774873,0.0001707571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979069,0.00006864141,0.00003904669,0.00008302956,0.0002119077,0.00009833316,0.000147568,0.00004222905,0.001402394],"genre_scores_gemma":[0.999226,0.00001026441,0.0001445821,0.0001122716,0.0001784001,0.00001600156,0.0002478016,0.00002861473,0.00003611471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003285463,"threshold_uncertainty_score":0.6742794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055632950801765,"score_gpt":0.2403796578545976,"score_spread":0.22982332834658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}