{"id":"W2789041953","doi":"10.1016/j.bbrc.2018.01.176","title":"Hepatitis C virus regulates proprotein convertase subtilisin/kexin type 9 promoter activity","year":2018,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Hepatitis C virus research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Proprotein convertase; Kexin; PCSK9; Sterol regulatory element-binding protein; Biology; Transcription factor; NS5B; Promoter; Hepatitis C virus; Response element; NS5A; Transcription (linguistics); Molecular biology; Virology; Gene; Virus; LDL receptor; Biochemistry; Hepacivirus; Gene expression; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625636,0.0002242705,0.0001425989,0.000229185,0.0002318223,0.0004482502,0.0001055842,0.000248183,0.002772298],"category_scores_gemma":[0.000229102,0.0001733756,0.0002772305,0.0001002052,0.0002658954,0.0002255185,0.00029784,0.0005474712,0.0009507748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004094281,"about_ca_system_score_gemma":0.0002186299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418646,"about_ca_topic_score_gemma":0.001651184,"domain_scores_codex":[0.9998047,0.00003265961,0.00001023773,0.00003579473,0.00003006023,0.00008662973],"domain_scores_gemma":[0.9998187,0.00006942098,0.00002462764,0.00001755217,0.00002265105,0.00004697675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003568981,0.0000403627,0.0005964142,0.00001569864,0.000002348577,0.00004573278,0.00002989885,0.00002486638,0.9978107,0.0001308869,0.00009025382,0.0008560109],"study_design_scores_gemma":[0.00003806885,0.0002223254,0.02642814,0.00002029328,0.00001143715,0.0002106188,0.0001837978,0.001523959,0.9692583,0.0001547413,0.001938593,0.000009836192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953828,0.0007446709,0.001365421,0.0001298411,0.00006245101,0.000009905516,0.0004400907,0.00006129848,0.001803509],"genre_scores_gemma":[0.9949874,0.0002378502,0.0008792827,0.00005732129,0.000009824198,0.00001056031,0.0008685959,0.00002296829,0.002926291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002772298,"threshold_uncertainty_score":0.009274244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1248951299014535,"score_gpt":0.4216681438892469,"score_spread":0.2967730139877934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}