{"id":"W2789079364","doi":"10.18433/jpps29578","title":"In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Nitric oxide; Chemistry; Stimulation; Nitric oxide synthase; Myograph; Soluble guanylyl cyclase; Endothelium; Guanylate cyclase; Pharmacology; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004504905,0.0003125413,0.0003032063,0.0001827347,0.0002400535,0.0003461364,0.000308019,0.0008651649,0.01311718],"category_scores_gemma":[0.0005656568,0.0001367897,0.0004818899,0.000157068,0.0004268059,0.0004866957,0.0002130301,0.0007178786,0.003348044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002655084,"about_ca_system_score_gemma":0.0002413826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005974931,"about_ca_topic_score_gemma":0.0009060826,"domain_scores_codex":[0.9996069,0.00005351218,0.00003855841,0.00008744672,0.0001621597,0.00005138801],"domain_scores_gemma":[0.9996334,0.0001117533,0.00009568068,0.00004927549,0.00006894553,0.00004081694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003102156,0.00006853951,0.00195582,0.0006278732,0.00003052983,0.001621343,0.0001351387,0.00004530907,0.9653095,0.001543934,0.00674285,0.02160901],"study_design_scores_gemma":[0.0001383454,0.002681667,0.07458074,0.0002123136,0.0001799736,0.008049922,0.0003990103,0.0005725186,0.7231177,0.002085506,0.1879143,0.00006796139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8081476,0.06838006,0.01674659,0.02678902,0.01350162,0.0003556274,0.00269087,0.001178581,0.06221002],"genre_scores_gemma":[0.8973513,0.03093809,0.005627035,0.008310395,0.002862868,0.0001318298,0.001310057,0.0001090023,0.05335932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01311718,"threshold_uncertainty_score":0.04388136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0662474788311559,"score_gpt":0.3805186026200541,"score_spread":0.3142711237888982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}