{"id":"W2789082224","doi":"10.1016/s2213-2600(18)30052-3","title":"DNA methylation in childhood asthma: an epigenome-wide meta-analysis","year":2018,"lang":"en","type":"review","venue":"The Lancet Respiratory Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":252,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi; McGill University and Génome Québec Innovation Centre; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill Genome Centre","funders":"Generalitat de Catalunya; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Centres de Recerca de Catalunya","keywords":"DNA methylation; CpG site; Epigenome; Asthma; Medicine; Methylation; Epigenomics; Epigenetics; Differentially methylated regions; Whole blood; Cord blood; Immunology; Allergy; Bioinformatics; Genetics; Biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004139942,0.0005321731,0.003151145,0.0003974218,0.0001170259,0.00002528498,0.0007653463,0.00045809,0.0002036179],"category_scores_gemma":[0.0004960854,0.0003029006,0.0009811734,0.0009831631,0.0002284934,0.000006648208,0.0001361523,0.000383761,0.00002771129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004314753,"about_ca_system_score_gemma":0.0001823776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003403669,"about_ca_topic_score_gemma":0.0003936808,"domain_scores_codex":[0.9958003,0.001544569,0.001026591,0.0008161169,0.0003865619,0.0004258601],"domain_scores_gemma":[0.9970917,0.0001649302,0.0006846428,0.00178972,0.0001350082,0.0001339661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001813071,0.000669946,0.0009755475,0.005062574,0.2235166,0.00005470929,0.001483413,0.0004077409,0.002379596,0.0005161086,0.007696741,0.7570558],"study_design_scores_gemma":[0.0002932424,0.0003939204,0.0006761402,0.0000929294,0.04893139,5.991491e-7,0.00001339274,0.000002056884,0.000167882,0.0001400351,0.9489727,0.0003156885],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007829056,0.9965273,0.0005018153,0.0001908426,0.0001470469,0.0006730268,0.00004897319,0.00001738647,0.00111068],"genre_scores_gemma":[0.001112792,0.9934745,0.000142974,0.0006119669,0.003410912,0.0001599637,0.0008176521,0.00006970047,0.0001995747],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.941276,"threshold_uncertainty_score":0.9999423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1757279406265098,"score_gpt":0.396988755059422,"score_spread":0.2212608144329122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}