{"id":"W2789089139","doi":"10.1182/blood-2017-07-795278","title":"Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Cell biology; Cellular differentiation; Biology; Mechanism (biology); Chemistry; Cancer research; Genetics; Physics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007486378,0.00006925564,0.000102785,0.00004712357,0.00001399695,0.000003453038,0.00004564241,0.00008358494,0.00001290318],"category_scores_gemma":[0.00002342386,0.00007111673,0.00002753031,0.00005465388,0.00004694035,0.000003667691,0.00002139001,0.0000271854,8.274513e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002960142,"about_ca_system_score_gemma":0.00002250214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004970093,"about_ca_topic_score_gemma":0.0003028701,"domain_scores_codex":[0.9994967,0.00003547718,0.0001623608,0.0001441617,0.00008236438,0.00007894644],"domain_scores_gemma":[0.999703,0.000007062365,0.00009327821,0.0001053675,0.00006986031,0.00002142105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006615898,0.0001290149,0.01099048,0.00002814052,0.00002161821,2.70147e-7,0.0002269524,0.000002356044,0.9880322,0.0003816265,0.000002629191,0.0001185738],"study_design_scores_gemma":[0.001392208,0.0003505579,0.07142939,0.00001799312,0.00002360489,0.000001292395,0.00005228136,0.0001338904,0.9262218,0.0002793512,0.00003499174,0.00006268323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982892,0.00006299971,0.0009741797,0.00001155154,0.00005236467,0.0000994066,0.00001415017,0.000003271831,0.0004928882],"genre_scores_gemma":[0.999532,0.00001798601,0.0003022046,0.000003776446,0.00003065951,0.000003851168,0.00004469193,0.000007979008,0.00005686639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06181042,"threshold_uncertainty_score":0.2900056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007061226995222686,"score_gpt":0.215547549937624,"score_spread":0.2084863229424013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}