{"id":"W2789228913","doi":"10.1016/j.matbio.2018.01.021","title":"Design of peptide mimetics to block pro-inflammatory functions of HA fragments","year":2018,"lang":"en","type":"review","venue":"Matrix Biology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Victoria Hospital; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Breast Cancer Society of Canada; Cancer Research Society","keywords":"Inflammation; Peptide; Context (archaeology); Extracellular matrix; Cell biology; Receptor; Chemistry; Proinflammatory cytokine; Signal transduction; Extracellular; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002272502,0.0005920809,0.0005934046,0.0004708935,0.0000957739,0.0004119162,0.0004847359,0.00049232,0.0008696943],"category_scores_gemma":[0.0002424239,0.0001814157,0.0002165028,0.0003849363,0.000195695,0.0005011306,0.0002623544,0.001060181,0.000525518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261162,"about_ca_system_score_gemma":0.000222197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002395797,"about_ca_topic_score_gemma":0.0003637459,"domain_scores_codex":[0.9999375,0.000007773743,0.000006925059,0.00001277759,0.00002209467,0.0000129334],"domain_scores_gemma":[0.9999515,0.00001617502,0.00001462825,0.000002100559,0.000009696959,0.000005895367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003497378,0.0002428876,0.0001995758,0.01129093,0.0001277373,0.0005702078,0.00006994721,0.001278237,0.1501449,0.005568136,0.008652243,0.8215055],"study_design_scores_gemma":[0.000164411,0.0008313756,0.001415664,0.001093713,0.0002845987,0.002232848,0.00005146283,0.001035446,0.104856,0.001856286,0.8861169,0.0000613148],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007005048,0.9870256,0.002727804,0.0002687138,0.0002931108,0.00004834689,0.00007586646,0.00004471368,0.002510758],"genre_scores_gemma":[0.03041266,0.9619355,0.003341259,0.0004332424,0.0001369221,0.0000802517,0.0001654355,0.000008180997,0.00348657],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008696943,"threshold_uncertainty_score":0.002909422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04927069515798014,"score_gpt":0.3621529276919974,"score_spread":0.3128822325340172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}