{"id":"W2789259233","doi":"10.1001/jamaneurol.2017.5135","title":"Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease","year":2018,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Montreal Neurological Institute and Hospital; Avid Radiopharmaceuticals; University of California, San Diego; National Institutes of Health; Wake Forest School of Medicine; Organisation de Coopération et de Développement Économiques; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Eisai; Canada Research Chairs; Alzheimer Society; Alzheimer's Society; Genentech; Vrije Universiteit Amsterdam; Weston Brain Institute; Novartis Pharma; Fondation Brain Canada; Fondation pour la Recherche Médicale; McGill University; Canadian Institutes of Health Research; Foundation for Barnes-Jewish Hospital; National Center for Research Resources; F. Hoffmann-La Roche; Biogen; Pfizer; National Center for Advancing Translational Sciences; Cure Alzheimer's Fund; TauRx Pharmaceuticals; Consortium canadien en neurodégénérescence associée au vieillissement; Glenn Foundation for Medical Research; Alzheimer's Association; Sanofi; BrightFocus Foundation; Eli Lilly and Company; Johns Hopkins University","keywords":"Asymptomatic; Cohort; Medicine; Dementia; Disease; Alzheimer's disease; Cohort study; Family history; Pittsburgh compound B; Internal medicine; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993042,0.0001217161,0.0001918422,0.0002042951,0.00004964711,0.00002215295,0.00008303644,0.00008037219,0.0004574807],"category_scores_gemma":[0.0001565105,0.0001068875,0.00003147681,0.0001898983,0.0002369405,0.00008020415,0.0001473497,0.0002792626,0.0002053728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001095069,"about_ca_system_score_gemma":0.00008247521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009694301,"about_ca_topic_score_gemma":0.00004875378,"domain_scores_codex":[0.9987139,0.0001302783,0.0001631154,0.0003926751,0.0002098248,0.0003901858],"domain_scores_gemma":[0.9992401,0.00006086736,0.00002461357,0.00020051,0.00006889837,0.0004049984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002475193,0.0001852975,0.9824374,0.00001524949,0.00002719951,0.0006821007,0.0001730805,1.284573e-7,0.0004428118,0.00002926961,0.001935065,0.01159722],"study_design_scores_gemma":[0.001912748,0.001947796,0.9861246,0.00001608601,0.00006489748,0.0001035882,0.00002743685,0.0001813801,0.0003543033,0.0001722695,0.009007166,0.00008769074],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800084,0.0001165521,0.000006536344,0.01748964,0.00009675802,0.0006956713,0.0000160223,0.00003049104,0.00153997],"genre_scores_gemma":[0.9913191,0.00002129894,0.00002454098,0.007995565,0.0003205896,0.00006991364,0.0000236107,0.00001521987,0.0002102183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01150953,"threshold_uncertainty_score":0.5009093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863860577607741,"score_gpt":0.3107968557922691,"score_spread":0.2921582500161917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}