{"id":"W2789295860","doi":"10.1158/1538-7445.sabcs17-ot1-01-01","title":"Abstract OT1-01-01: IMpassion131: A phase III study comparing 1L atezolizumab with paclitaxel vs placebo with paclitaxel in treatment-naive patients with inoperable locally advanced or metastatic triple negative breast cancer (TNBC)","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Health Services","funders":"","keywords":"Atezolizumab; Medicine; Internal medicine; Triple-negative breast cancer; Oncology; Taxane; Paclitaxel; Metastatic breast cancer; Chemotherapy; Breast cancer; Placebo; Cancer; Immunotherapy; Pathology; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00159228,0.00158508,0.002225801,0.0004304605,0.0004402786,0.001023983,0.001285869,0.001774543,0.006387098],"category_scores_gemma":[0.0009016898,0.0007371876,0.001827431,0.0005593688,0.001154489,0.000821773,0.0003943218,0.003850885,0.001212767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000951333,"about_ca_system_score_gemma":0.001879769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184706,"about_ca_topic_score_gemma":0.002869933,"domain_scores_codex":[0.9996233,0.0001743365,0.00002271472,0.00007012932,0.00003611973,0.0000733452],"domain_scores_gemma":[0.999283,0.0001265046,0.0001457135,0.00005961974,0.00005190058,0.0003332144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8780168,0.05520435,0.001869104,0.001284711,0.001188215,0.0001179568,0.0001235778,0.000651374,0.02424065,0.0001607012,0.002387509,0.03475507],"study_design_scores_gemma":[0.6772727,0.3145067,0.004113131,0.00004134746,0.000556466,0.0001063067,0.00002784153,0.0004085793,0.001710185,0.00008770746,0.001145348,0.00002359593],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823266,0.003296679,0.0007487902,0.0006423831,0.0003169114,0.006908995,0.002930413,0.0001710871,0.002658198],"genre_scores_gemma":[0.9782883,0.002563623,0.002016742,0.00173822,0.0004331872,0.005769138,0.004233506,0.0000520739,0.004905186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006387098,"threshold_uncertainty_score":0.02136695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06763732471246466,"score_gpt":0.4113377107985923,"score_spread":0.3437003860861277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}