{"id":"W2789318789","doi":"10.1093/jcag/gwy009.271","title":"A271 THE HELICOBACTER PYLORI VACA TOXIN IMPAIRS LYSOSOMAL CALCIUM CHANNEL TRPML1 ACTIVITY TO PROMOTE COLONIZATION","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Microbial Metabolites in Food Biotechnology","field":"Nursing","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Intracellular; Biology; Vacuole; Autophagy; Lysosome; Cell biology; Helicobacter pylori; Calcium in biology; Endosome; Cytoplasm; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00131664,0.0001713148,0.0004083832,0.0003624736,0.0003013792,0.00004103017,0.0007598539,0.0003473276,0.00004850944],"category_scores_gemma":[0.00124004,0.0001211353,0.0002042691,0.0004001807,0.0001715032,0.0001280541,0.00009979848,0.0005730093,0.00001575985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00235549,"about_ca_system_score_gemma":0.0001996208,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003154476,"about_ca_topic_score_gemma":0.2666308,"domain_scores_codex":[0.9976849,0.0006641932,0.0005626715,0.0001736662,0.0003060019,0.0006085797],"domain_scores_gemma":[0.9972431,0.00006865261,0.001411074,0.000328178,0.0007457901,0.0002031799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005801335,0.0004107664,0.382098,0.00004526101,0.001182847,0.00001368456,0.0046966,0.0002240085,0.5028868,0.0002803289,0.09808546,0.004274862],"study_design_scores_gemma":[0.003875407,0.009482454,0.7086678,0.0001461154,0.0005078394,0.0004330047,0.0002282936,0.0003493726,0.2038235,0.0007042994,0.07145829,0.0003236741],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8716437,0.00000691961,0.0001786393,0.1236749,0.004045011,0.0003255732,0.00006081351,0.00001032339,0.00005417133],"genre_scores_gemma":[0.9937879,0.000001800838,0.0002398374,0.00495461,0.0008496636,0.000003700209,0.000001567983,0.0000233647,0.0001375066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3265698,"threshold_uncertainty_score":0.7467512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130215443847476,"score_gpt":0.2432928355768061,"score_spread":0.2319906811383314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}