{"id":"W2789336047","doi":"10.3390/v10030100","title":"DNA Vaccine-Encoded Flagellin Can Be Used as an Adjuvant Scaffold to Augment HIV-1 gp41 Membrane Proximal External Region Immunogenicity","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Immunogenicity; Augment; Flagellin; DNA vaccination; Adjuvant; Virology; Biology; Human immunodeficiency virus (HIV); DNA; Computational biology; Genetics; Gene; Antibody; Immunology; Plasmid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002817293,0.00033561,0.0004031842,0.0001974041,0.0004171806,0.00005737759,0.0004776507,0.0002084195,0.002121135],"category_scores_gemma":[0.00007160995,0.0002695225,0.0001190827,0.000199722,0.0001657079,0.0001844112,0.0001851193,0.0002172556,0.005551606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00016317,"about_ca_system_score_gemma":0.0002061966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002509216,"about_ca_topic_score_gemma":0.002291756,"domain_scores_codex":[0.9976798,0.0003601398,0.0003779235,0.0006263268,0.0001454124,0.0008104161],"domain_scores_gemma":[0.9988814,0.00008401049,0.0001038932,0.0006126618,0.0001328981,0.0001851595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002199422,0.0006438858,0.006513435,0.0000125468,0.000272109,0.00009317268,0.001067486,0.000002671254,0.9818842,0.00025645,0.004390568,0.002664078],"study_design_scores_gemma":[0.003229144,0.002544935,0.005950728,0.00006258857,0.00006356267,0.0001241998,0.000170295,0.000005201041,0.9551551,0.00007911766,0.0323113,0.0003038458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963918,0.0006658781,0.0001474113,0.0008789134,0.0003075178,0.0008198119,0.000236146,0.0001536769,0.0003988811],"genre_scores_gemma":[0.9950165,0.00008629001,0.0002892879,0.001110046,0.0001650983,0.0001285095,0.0001754552,0.00003929144,0.002989542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02792073,"threshold_uncertainty_score":0.9999757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0376533589902037,"score_gpt":0.3012052969473175,"score_spread":0.2635519379571137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}