{"id":"W2789422248","doi":"10.1093/gbe/evy030","title":"Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli","year":2018,"lang":"en","type":"article","venue":"Genome Biology and Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba","keywords":"Biology; Antibiotic resistance; Experimental evolution; Trade-off; Genetics; Antibiotics; Trait; Drug resistance; Escherichia coli; Evolutionary dynamics; Gene; Evolutionary biology; Ecology; Population; Demography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236622,0.0001080407,0.0001331167,0.00004631443,0.00006123689,0.000002940572,0.00009858576,0.0001927889,0.00001294528],"category_scores_gemma":[0.00006313919,0.0001086811,0.00003489587,0.0001286252,0.0004663758,0.00000252833,0.00004894828,0.00006465409,0.000005036078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001985988,"about_ca_system_score_gemma":0.0000680111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001785535,"about_ca_topic_score_gemma":0.0004238407,"domain_scores_codex":[0.9991551,0.00008865737,0.000215921,0.0002866751,0.00003592482,0.0002177352],"domain_scores_gemma":[0.9996237,0.000008262287,0.00008135232,0.0001729968,0.00006832845,0.00004533726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001398961,0.00004445499,0.06415164,0.00002215602,0.00001243922,6.29112e-7,0.00006086045,0.00001220405,0.9325428,0.00280081,0.00004128929,0.0001708455],"study_design_scores_gemma":[0.00055629,0.0004658588,0.9916182,0.00001671486,0.00001124754,0.00001095644,0.00006773501,0.0003434095,0.003055576,0.001607314,0.002081194,0.0001655391],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862934,0.003338876,0.009211421,0.000070831,0.000112078,0.0001121378,0.00003169546,0.000007114443,0.000822434],"genre_scores_gemma":[0.9968049,0.0001742544,0.002445977,0.00005127716,0.0001292714,0.000003424193,0.00008421043,0.000007751543,0.000298929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9294872,"threshold_uncertainty_score":0.4431888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007909289906783672,"score_gpt":0.2423967496017124,"score_spread":0.2344874596949287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}