{"id":"W2789422248","doi":"10.1093/gbe/evy030","title":"Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli","year":2018,"lang":"en","type":"article","venue":"Genome Biology and Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba","keywords":"Biology; Antibiotic resistance; Experimental evolution; Trade-off; Genetics; Antibiotics; Trait; Drug resistance; Escherichia coli; Evolutionary dynamics; Gene; Evolutionary biology; Ecology; Population; Demography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00038901,0.0002696318,0.0002640437,0.0005159773,0.0002030716,0.0005216368,0.0002791417,0.0003607083,0.00030769],"category_scores_gemma":[0.001533891,0.0001548472,0.0001845456,0.0004534815,0.000375975,0.0003067875,0.0004567733,0.0003490173,0.00006845302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004963964,"about_ca_system_score_gemma":0.0001474907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009241452,"about_ca_topic_score_gemma":0.001449501,"domain_scores_codex":[0.9995406,0.0001908558,0.00003267073,0.0001038209,0.00008580691,0.00004634259],"domain_scores_gemma":[0.9991751,0.0003655862,0.0002572019,0.00008391716,0.0000622409,0.00005590034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004039309,0.0001968366,0.1694182,0.00007573874,0.0001231164,0.0003051776,0.000215775,0.005516839,0.8027256,0.0004157342,0.00007662144,0.02052645],"study_design_scores_gemma":[0.0000194434,0.0004735664,0.9019912,0.000008566989,0.00004686399,0.001124046,0.0003514367,0.01985661,0.07422572,0.001274046,0.0005762879,0.00005230011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992042,0.0000793707,0.0005209933,0.00001335492,7.190746e-7,0.000002274374,0.00003369104,0.000004780688,0.0001405101],"genre_scores_gemma":[0.9991351,0.00007633598,0.0006386309,0.00001323949,0.000001351613,0.000004613071,0.00006564858,0.000004174364,0.00006096096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009241452,"threshold_uncertainty_score":0.00360167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007909289906783672,"score_gpt":0.2423967496017124,"score_spread":0.2344874596949287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}