{"id":"W2789451500","doi":"10.1089/humc.2017.249","title":"A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy Clinical Development","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"WOMAC; Medicine; Osteoarthritis; Visual analogue scale; Placebo; Knee pain; Clinical trial; Internal medicine; Patella; Adverse effect; Urology; Physical therapy; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001726149,0.001197447,0.002689328,0.0003742336,0.0004467787,0.0007255158,0.0006245167,0.001500416,0.004104657],"category_scores_gemma":[0.001002531,0.0004417576,0.0009912589,0.0004361982,0.00125609,0.0007307822,0.0002687623,0.001866009,0.0007900895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003902884,"about_ca_system_score_gemma":0.001299418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004090627,"about_ca_topic_score_gemma":0.0009268519,"domain_scores_codex":[0.9994438,0.0002499456,0.00004031284,0.0001177397,0.00005507106,0.00009318798],"domain_scores_gemma":[0.9991794,0.0001806199,0.0001686225,0.00007639144,0.00007519549,0.0003197328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9317166,0.02677858,0.00105359,0.0004338621,0.0004109072,0.00005034946,0.00005352745,0.0003243446,0.01888626,0.0001116238,0.0006036688,0.0195767],"study_design_scores_gemma":[0.7461592,0.2504738,0.001683125,0.00001499952,0.0001168439,0.00003240065,0.00001416101,0.000223528,0.0008601825,0.00005168473,0.000361388,0.000008746987],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912652,0.00226756,0.000780429,0.000298933,0.0002647786,0.003497779,0.0005423806,0.00007886482,0.001004021],"genre_scores_gemma":[0.9827032,0.001750499,0.002683987,0.001117574,0.0004074162,0.007440337,0.001086309,0.00002103511,0.002789649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004104657,"threshold_uncertainty_score":0.01373142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1310568444743981,"score_gpt":0.4169022474667948,"score_spread":0.2858454029923968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}