{"id":"W2789457030","doi":"10.1016/j.ijrobp.2017.12.021","title":"A Randomized, Open-Label, Multicenter, Global Phase 2 Study of Durvalumab (D), Tremelimumab (T), or D Plus T, in Patients With PD-L1 Low/Negative Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: CONDOR","year":2018,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Durvalumab; Medicine; Tremelimumab; Head and neck squamous-cell carcinoma; Internal medicine; Immunotherapy; Oncology; Phases of clinical research; Cancer; Head and neck cancer; Gastroenterology; Clinical trial; Ipilimumab; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001464879,0.001878893,0.002044768,0.000381609,0.000371195,0.001051957,0.0008802874,0.001179906,0.004293464],"category_scores_gemma":[0.001031325,0.0006373975,0.001537128,0.0004324864,0.001248494,0.001305655,0.000442428,0.002534217,0.0009779619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009612826,"about_ca_system_score_gemma":0.001539727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001394394,"about_ca_topic_score_gemma":0.003757985,"domain_scores_codex":[0.9995936,0.0001892874,0.00001589046,0.00008847076,0.00002681921,0.00008599809],"domain_scores_gemma":[0.9994367,0.0001024529,0.00009947077,0.00006006134,0.00003173781,0.0002695814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.957756,0.01205225,0.001207416,0.0003651957,0.0008707801,0.00004669857,0.00009551435,0.0006116711,0.005463787,0.0001742154,0.001386217,0.01997019],"study_design_scores_gemma":[0.9456995,0.05083757,0.001627257,0.00001118236,0.0002676617,0.00003582083,0.0000310251,0.0003783292,0.0003372905,0.0001283951,0.0006318042,0.0000141244],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909451,0.001876794,0.0006983105,0.0005941067,0.0003166086,0.002384718,0.001179389,0.0001198946,0.00188512],"genre_scores_gemma":[0.9860073,0.001721313,0.00208758,0.001453547,0.0002542326,0.003255981,0.001927493,0.00004944337,0.003243112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004293464,"threshold_uncertainty_score":0.01436311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04009503983047163,"score_gpt":0.3797814049228379,"score_spread":0.3396863650923662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}