{"id":"W2789487757","doi":"10.1159/000486445","title":"Humanized Exposures of a β-Lactam-β-Lactamase Inhibitor, Tazobactam, versus Non-β-Lactam-β-Lactamase Inhibitor, Avibactam, with or without Colistin, against <b><i>Acinetobacter baumannii</i></b> in Murine Thigh and Lung Infection Models","year":2018,"lang":"en","type":"article","venue":"Pharmacology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Colistin; Acinetobacter baumannii; Avibactam; Tazobactam; Microbiology; Beta-Lactamase Inhibitors; Antibiotics; Pharmacology; Carbapenem; Medicine; Chemistry; Biology; Antibiotic resistance; Pseudomonas aeruginosa; Enterobacteriaceae; Bacteria; Biochemistry; Escherichia coli; Imipenem","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001021734,0.001568008,0.001887704,0.000725834,0.0004984518,0.0001809693,0.0007955784,0.001171698,0.0004335986],"category_scores_gemma":[0.0002889056,0.001421529,0.0003248776,0.0008587968,0.001761147,0.0002503898,0.0007506392,0.0007794764,0.00003825489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004094575,"about_ca_system_score_gemma":0.0007592659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008699606,"about_ca_topic_score_gemma":0.003207847,"domain_scores_codex":[0.9923613,0.0007415919,0.001985301,0.002254208,0.0008027626,0.001854842],"domain_scores_gemma":[0.9953225,0.0003037417,0.001392207,0.001252141,0.00102798,0.0007014529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0246951,0.001188372,0.01159776,0.0004625692,0.0007051249,0.0001878547,0.0006948376,0.0001495933,0.9433529,0.0001379043,0.01639802,0.0004299645],"study_design_scores_gemma":[0.05384016,0.009793394,0.03493532,0.0007805522,0.001519808,0.0002797629,0.0001563891,0.007385292,0.8175094,0.00007734496,0.06972481,0.003997791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901018,0.0009605304,0.0005975045,0.0002334341,0.00245814,0.002390408,0.0002013861,0.0001659684,0.002890804],"genre_scores_gemma":[0.9917347,0.001683499,0.001279175,0.0006354788,0.002463145,0.0002211522,0.0005263799,0.0003143758,0.001142096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1258435,"threshold_uncertainty_score":0.9997068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521887661487411,"score_gpt":0.2807662370926416,"score_spread":0.2655473604777675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}