{"id":"W2789493354","doi":"10.3389/fnbeh.2018.00015","title":"EGR3 Immediate Early Gene and the Brain-Derived Neurotrophic Factor in Bipolar Disorder","year":2018,"lang":"en","type":"article","venue":"Frontiers in Behavioral Neuroscience","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Mental Health; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina; Ministério da Ciência, Tecnologia e Inovação; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Neurotrophin; Neurotrophic factors; Neuroscience; Brain-derived neurotrophic factor; Bipolar disorder; Psychology; Neuroplasticity; Mood disorders; Transcription factor; Prefrontal cortex; Synaptic plasticity; Psychiatry; Biology; Gene; Cognition; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483446,0.0002109406,0.0003130355,0.0002239837,0.0001473937,0.00005401633,0.0002244887,0.00007375296,0.000008985665],"category_scores_gemma":[0.0000757401,0.0001440549,0.00005175771,0.0006072635,0.001280925,0.0001811432,0.0001113869,0.0003171834,0.000005070879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004422602,"about_ca_system_score_gemma":0.00005952419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006855684,"about_ca_topic_score_gemma":0.0002476843,"domain_scores_codex":[0.9983409,0.0001282053,0.0002569153,0.0005228668,0.0003025643,0.0004485679],"domain_scores_gemma":[0.9993925,0.00002477494,0.0000607586,0.0003556082,0.00003002062,0.0001363259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001875528,0.0002438805,0.9681555,0.000004641707,0.000001349253,0.00003975092,0.0007735493,6.06961e-7,0.0202742,0.00001090315,0.00004301425,0.01026507],"study_design_scores_gemma":[0.003800876,0.0006719333,0.9918242,0.00001398152,0.00002629006,0.0000284551,0.00004881393,0.0003541065,0.001207716,0.00007296793,0.001813451,0.0001372625],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928614,0.003151729,0.0003373003,0.001951999,0.0009362397,0.0006920897,0.00002115302,0.00003097965,0.00001709204],"genre_scores_gemma":[0.9980187,0.0004212555,0.0004931227,0.0008431344,0.00004259363,0.00004972256,0.00000307336,0.00002307766,0.0001053268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02366866,"threshold_uncertainty_score":0.5874389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02125035996270585,"score_gpt":0.2782238078153238,"score_spread":0.2569734478526179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}