{"id":"W2789493354","doi":"10.3389/fnbeh.2018.00015","title":"EGR3 Immediate Early Gene and the Brain-Derived Neurotrophic Factor in Bipolar Disorder","year":2018,"lang":"en","type":"article","venue":"Frontiers in Behavioral Neuroscience","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Mental Health; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina; Ministério da Ciência, Tecnologia e Inovação; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Neurotrophin; Neurotrophic factors; Neuroscience; Brain-derived neurotrophic factor; Bipolar disorder; Psychology; Neuroplasticity; Mood disorders; Transcription factor; Prefrontal cortex; Synaptic plasticity; Psychiatry; Biology; Gene; Cognition; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113582,0.0002613278,0.0001991945,0.0001829495,0.0001984196,0.0002376464,0.000138128,0.0003797533,0.002403635],"category_scores_gemma":[0.0001309864,0.0000912068,0.0002730489,0.0002506103,0.0001441904,0.0001116088,0.0001593456,0.0003644045,0.0002856748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221401,"about_ca_system_score_gemma":0.0002742718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006042145,"about_ca_topic_score_gemma":0.008200143,"domain_scores_codex":[0.9999602,0.000008506658,0.000003407042,0.0000102081,0.00000746403,0.00001014499],"domain_scores_gemma":[0.9999756,0.000003165746,0.000009334178,0.000001279289,0.000003656349,0.000006950458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01206117,0.0005575229,0.3921324,0.002196136,0.0007858101,0.0156367,0.0007595642,0.001425917,0.1340894,0.006902867,0.03627806,0.3971745],"study_design_scores_gemma":[0.0002860341,0.0004114996,0.9433188,0.0007258501,0.0006298019,0.01154413,0.0005593457,0.001426653,0.004179418,0.007477895,0.02940397,0.00003665152],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8523213,0.1105986,0.00240144,0.009023742,0.0007191923,0.00007436104,0.002559935,0.0001281344,0.02217339],"genre_scores_gemma":[0.9626032,0.02768109,0.002091261,0.001234672,0.0001912489,0.00005317073,0.001380989,0.00001327418,0.004751068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006042145,"threshold_uncertainty_score":0.01201397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02125035996270585,"score_gpt":0.2782238078153238,"score_spread":0.2569734478526179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}