{"id":"W2789504137","doi":"10.3390/v10050272","title":"Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Nova Scotia Health Authority; Hospital for Sick Children; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Dalhousie University; Albert-Ludwigs-Universität Freiburg; Public Health Agency; Public Health Agency of Canada; University of Wisconsin-Madison","keywords":"Polymerase; Biology; Virology; Virulence; Influenza A virus; Polymerase chain reaction; Virus; Serial passage; Reverse genetics; Genome; Host adaptation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002643663,0.0001752513,0.0002545754,0.0003230782,0.0002406379,0.00002642838,0.00004271021,0.00008300789,0.00007657589],"category_scores_gemma":[0.001179456,0.0001549319,0.00003195656,0.0004713516,0.0005212985,0.0003685204,0.00007844507,0.0002594845,0.0003193103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001433442,"about_ca_system_score_gemma":0.0001096047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001279833,"about_ca_topic_score_gemma":0.0006238983,"domain_scores_codex":[0.9986857,0.0001075864,0.0002191028,0.0003771506,0.0002821759,0.000328237],"domain_scores_gemma":[0.9992664,0.0001130886,0.00008222312,0.0002360308,0.0001973581,0.0001049045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002476972,0.0006838319,0.1447471,0.0001229925,0.0001748227,0.00003770946,0.00251316,0.0000266148,0.7785267,0.0001078571,0.001121243,0.06946097],"study_design_scores_gemma":[0.00137561,0.001079159,0.2187622,0.0001991623,0.00005792223,0.00003326371,0.0002019458,0.0001532552,0.7687991,0.000298514,0.008771061,0.0002687947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962951,0.000891979,0.0001106597,0.0003269195,0.0001176086,0.0005956454,0.00003793931,0.0001064279,0.001517726],"genre_scores_gemma":[0.9978896,0.0002050604,0.0001838445,0.001160615,0.000342998,0.0001012522,0.000001932101,0.00002099402,0.0000937424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07401509,"threshold_uncertainty_score":0.631794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07189987975345802,"score_gpt":0.3929676178818552,"score_spread":0.3210677381283972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}