{"id":"W2789504137","doi":"10.3390/v10050272","title":"Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Nova Scotia Health Authority; Hospital for Sick Children; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Dalhousie University; Albert-Ludwigs-Universität Freiburg; Public Health Agency; Public Health Agency of Canada; University of Wisconsin-Madison","keywords":"Polymerase; Biology; Virology; Virulence; Influenza A virus; Polymerase chain reaction; Virus; Serial passage; Reverse genetics; Genome; Host adaptation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172004,0.0003394621,0.0002000509,0.0001886623,0.00009790409,0.0002002482,0.0001639158,0.0002170664,0.0005441565],"category_scores_gemma":[0.0001216357,0.0001404354,0.0002192214,0.0001032616,0.0001697324,0.0001159232,0.0001637913,0.0004755326,0.0001638767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222029,"about_ca_system_score_gemma":0.0001693523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009216027,"about_ca_topic_score_gemma":0.00205787,"domain_scores_codex":[0.9998478,0.00002209471,0.00001460154,0.00003939152,0.00004677315,0.00002934407],"domain_scores_gemma":[0.9999229,0.00001494542,0.00002641929,0.00001007027,0.00001015576,0.00001552714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004291481,0.00001957844,0.0004514919,0.00001037708,0.000004418825,0.00001156498,0.000005241797,0.00003984433,0.9984943,0.00002328332,0.00002227274,0.0008746901],"study_design_scores_gemma":[0.00001394437,0.0005823827,0.01291128,0.000005351608,0.00002204598,0.0002197863,0.00001413488,0.0008059423,0.9839658,0.00003543985,0.001418496,0.000005447368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968293,0.0006697059,0.001353599,0.00003261432,0.00001050917,0.00001498872,0.0002082251,0.00004287292,0.0008381816],"genre_scores_gemma":[0.9949244,0.0005160103,0.00310823,0.00003941129,0.000006678003,0.0000166266,0.0004560107,0.00002417145,0.0009083721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009216027,"threshold_uncertainty_score":0.001832485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07189987975345802,"score_gpt":0.3929676178818552,"score_spread":0.3210677381283972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}