{"id":"W2789521745","doi":"10.1200/jco.2018.36.6_suppl.161","title":"SPARTAN, a phase 3 double-blind, randomized study of apalutamide (APA) versus placebo (PBO) in patients (pts) with nonmetastatic castration-resistant prostate cancer (nmCRPC).","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Prostate cancer; Internal medicine; Abiraterone acetate; Clinical endpoint; Randomization; Metastasis; Oncology; Urology; Randomized controlled trial; Doubling time; Cancer; Placebo; Androgen deprivation therapy; Pathology; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001973799,0.001744125,0.002932381,0.0006162337,0.0004651492,0.001043932,0.001071921,0.001644437,0.006754916],"category_scores_gemma":[0.001907157,0.0008606205,0.001536701,0.0004660808,0.001336268,0.001073097,0.0003709997,0.002647141,0.001094771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006417133,"about_ca_system_score_gemma":0.001833959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009165203,"about_ca_topic_score_gemma":0.002346446,"domain_scores_codex":[0.9992751,0.0004423749,0.00004338697,0.0001080569,0.00004973871,0.00008131892],"domain_scores_gemma":[0.9990041,0.000316554,0.0002030962,0.00006814681,0.00006222341,0.0003460447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9786081,0.007793572,0.0002649721,0.0004546115,0.0004814177,0.00002239928,0.00003892878,0.0002383454,0.002349235,0.0000747041,0.0003659443,0.009307704],"study_design_scores_gemma":[0.9216495,0.07660762,0.0005889109,0.00001424997,0.0001932351,0.00001784053,0.00001214357,0.0003028801,0.0002738312,0.0000904643,0.0002408065,0.00000862723],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803196,0.004137686,0.001139662,0.0005088678,0.000643332,0.008786881,0.00146574,0.0002997532,0.0026986],"genre_scores_gemma":[0.9815294,0.002625285,0.002217089,0.001037939,0.0003760046,0.007811353,0.0009537608,0.00003722914,0.003411787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006754916,"threshold_uncertainty_score":0.02259743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2004344956586704,"score_gpt":0.526148373794619,"score_spread":0.3257138781359487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}