{"id":"W2789548112","doi":"10.1093/hmg/ddy099","title":"Protein synthesis levels are increased in a subset of individuals with fragile X syndrome","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; Novartis Pharma; Université de Lausanne; Fonds Wetenschappelijk Onderzoek; Odense Universitetshospital; National Science Foundation; Fondazione Cariplo; National Institute of Child Health and Human Development; Fondation Jérôme Lejeune; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Fragile X syndrome; Genetics; Fragile x; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001548844,0.0002631539,0.0002704557,0.0001405499,0.00007052486,0.00002197958,0.0003469823,0.0001611655,0.00006343416],"category_scores_gemma":[0.00004730617,0.0002633075,0.00006678775,0.0002276692,0.000265816,0.000002385295,0.0001753537,0.00009062779,0.000009588704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001222409,"about_ca_system_score_gemma":0.00009473423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002935195,"about_ca_topic_score_gemma":0.0001750469,"domain_scores_codex":[0.9984105,0.000113402,0.0003437147,0.0004926709,0.0002892522,0.0003504828],"domain_scores_gemma":[0.9990584,0.000006426942,0.0001802807,0.0005353301,0.0001194035,0.0001001091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003087763,0.000155949,0.02861163,0.00004023059,0.0000661771,0.00003894087,0.00006983758,0.00004989408,0.970681,0.00003933728,0.00005782908,0.0001583205],"study_design_scores_gemma":[0.0005207051,0.0005367131,0.4240482,0.00007432602,0.00001951328,0.00001547725,0.00005887053,0.000008345233,0.5738827,0.0001311156,0.0004464466,0.0002575254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982672,0.0003342138,0.0002777528,0.00002898076,0.00001829821,0.0004731944,0.00007130802,0.00000894398,0.0005200471],"genre_scores_gemma":[0.996529,0.00001827686,0.003044075,0.0001499452,0.00001151564,0.00008866478,0.00004921438,0.00006149624,0.00004775864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3967983,"threshold_uncertainty_score":0.9999819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367422225906667,"score_gpt":0.2339683124213059,"score_spread":0.2202940901622392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}