{"id":"W2789548112","doi":"10.1093/hmg/ddy099","title":"Protein synthesis levels are increased in a subset of individuals with fragile X syndrome","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; Novartis Pharma; Université de Lausanne; Fonds Wetenschappelijk Onderzoek; Odense Universitetshospital; National Science Foundation; Fondazione Cariplo; National Institute of Child Health and Human Development; Fondation Jérôme Lejeune; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; Fragile X syndrome; Genetics; Fragile x; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009387427,0.000385475,0.0002962273,0.0006118401,0.0001958238,0.0001874622,0.00008876405,0.0002198515,0.001217878],"category_scores_gemma":[0.0002828797,0.0001226431,0.0001391865,0.0001981929,0.0001913256,0.00009425243,0.0001643925,0.0002058531,0.0001858364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008524174,"about_ca_system_score_gemma":0.00006700005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005215654,"about_ca_topic_score_gemma":0.0006048541,"domain_scores_codex":[0.9999055,0.00001132438,0.00001128841,0.00003597397,0.00002315129,0.00001279207],"domain_scores_gemma":[0.9998649,0.00001845884,0.00006779425,0.00001348789,0.00001139479,0.00002382436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001114125,0.00007526173,0.2993185,0.0000903008,0.0001172568,0.005229663,0.0004092021,0.0001291873,0.6784531,0.0001147422,0.0003098656,0.01463876],"study_design_scores_gemma":[0.00001239313,0.0005009035,0.9459399,0.0000103178,0.00007063139,0.01570492,0.0002324799,0.0001773273,0.03625438,0.0001625773,0.000924042,0.00001014467],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988992,0.0003691698,0.0002367755,0.00002542,0.000003481386,0.000003497246,0.0001587442,0.00001516791,0.0002884924],"genre_scores_gemma":[0.9988226,0.0002686967,0.0003099767,0.00001779279,0.000006450417,0.000005988604,0.0001772858,0.000004549364,0.0003865707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217878,"threshold_uncertainty_score":0.004074216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367422225906667,"score_gpt":0.2339683124213059,"score_spread":0.2202940901622392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}