{"id":"W2789549135","doi":"10.1093/jcag/gwy008.212","title":"A211 PROTEOLYTIC CLEAVAGE OF E-CADHERIN BY INFLAMMATORY PROTEASES PRODUCES BIOACTIVE PEPTIDES THAT MODIFY EPITHELIAL FUNCTION","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Proteases; Cell biology; Cell migration; Furin; Chemistry; Neutrophil elastase; Cleavage (geology); Cell; Molecular biology; Biology; Biochemistry; Inflammation; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002772287,0.0005524207,0.000356288,0.0003440424,0.0001817694,0.0003306854,0.0001862775,0.0003205628,0.002138348],"category_scores_gemma":[0.0002627997,0.0001619403,0.0003655876,0.0003650674,0.0001725474,0.0002870505,0.0001480736,0.0003805498,0.0005410446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002218642,"about_ca_system_score_gemma":0.0001558408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002525253,"about_ca_topic_score_gemma":0.0004913264,"domain_scores_codex":[0.9998097,0.00002632775,0.00001979773,0.00004024599,0.00005845724,0.00004556912],"domain_scores_gemma":[0.999893,0.00002813428,0.0000293208,0.00001195311,0.00001685981,0.0000208082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009653327,0.00002978936,0.0002038599,0.00004973269,0.000005673234,0.00006703008,0.000004965873,0.00004931147,0.9974748,0.00002482579,0.00004242866,0.001950881],"study_design_scores_gemma":[0.00002523197,0.0005918928,0.007401597,0.000008743609,0.00002519381,0.0006806183,0.00001481062,0.0006262199,0.9879094,0.00003107189,0.002680077,0.000005265049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807216,0.006619867,0.008929102,0.0001484926,0.00004765799,0.0001082436,0.001496791,0.00009283716,0.001835407],"genre_scores_gemma":[0.9698048,0.005199185,0.0156493,0.0001506249,0.00002701029,0.0001167768,0.004300852,0.00002220924,0.004729086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002138348,"threshold_uncertainty_score":0.007153511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014704348671012,"score_gpt":0.2233766841548175,"score_spread":0.2132296406681074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}