{"id":"W2789587938","doi":"10.1016/j.celrep.2018.02.069","title":"Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioenergetics; Mitochondrion; Skeletal muscle; Oxidative stress; Redox; ATP–ADP translocase; Respiration; Biology; Electron transport chain; Oxidative phosphorylation; Biochemistry; Cell biology; Chemistry; Endocrinology; Inner mitochondrial membrane; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004307133,0.0002944213,0.0002460744,0.0005306575,0.000213206,0.0003962963,0.0002188607,0.0004173667,0.002098573],"category_scores_gemma":[0.0004231195,0.0002577168,0.0002564921,0.000325708,0.0002435468,0.0005168277,0.0005211291,0.0004592072,0.0004314542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001682327,"about_ca_system_score_gemma":0.000164665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000585629,"about_ca_topic_score_gemma":0.0008256421,"domain_scores_codex":[0.9998885,0.0000229091,0.00001661986,0.000024294,0.00002888243,0.00001877796],"domain_scores_gemma":[0.9996929,0.00003381386,0.0001197126,0.00004188936,0.00005837109,0.0000531851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002207779,0.000172457,0.06727875,0.0001950539,0.0001195281,0.002568783,0.0005412169,0.0002050933,0.90909,0.0005433636,0.0003937882,0.01668424],"study_design_scores_gemma":[0.00005826239,0.001330285,0.7910986,0.00007092497,0.0001555486,0.009457289,0.0006898132,0.001114581,0.1892353,0.002192765,0.004570236,0.00002634321],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913357,0.005352234,0.001916017,0.0001678722,0.00004131792,0.00001738875,0.0002305298,0.00001950528,0.0009193335],"genre_scores_gemma":[0.9956541,0.001848858,0.0005737488,0.00006046149,0.00003210822,0.00001198319,0.0002619459,0.000006803157,0.001549921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098573,"threshold_uncertainty_score":0.007020354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008494480561526335,"score_gpt":0.2523611632215108,"score_spread":0.2438666826599844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}