{"id":"W2789618179","doi":"10.1128/jvi.02141-17","title":"Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Neutralization; Virology; Biology; Immunogenicity; Epitope; Hypervariable region; Antibody; Neutralizing antibody; Hepatitis C virus; Infectivity; Monoclonal antibody; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283495,0.0002977861,0.0001323834,0.0001496068,0.0000727604,0.0002235913,0.000150977,0.0003182407,0.001022558],"category_scores_gemma":[0.0002011305,0.00007998215,0.0001850602,0.00005490602,0.0001031639,0.000173719,0.0001341521,0.0003003001,0.0002157617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597333,"about_ca_system_score_gemma":0.0001000343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002285832,"about_ca_topic_score_gemma":0.000136806,"domain_scores_codex":[0.9998696,0.00003720012,0.000008221732,0.00001671224,0.00002733741,0.00004095488],"domain_scores_gemma":[0.9998777,0.00003504562,0.00002765183,0.00001084969,0.00002111789,0.00002761312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002791859,0.00008724609,0.0009092076,0.00004361632,0.00001141628,0.00004394844,0.0000095968,0.0004000732,0.9955432,0.00009795011,0.00002937139,0.002545395],"study_design_scores_gemma":[0.00005222291,0.002093698,0.01412443,0.00001786446,0.00004500467,0.00051736,0.0000315017,0.004081491,0.9766003,0.0001301162,0.00229898,0.000006912604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971329,0.001030243,0.001020498,0.00003757898,0.00001126015,0.00001658066,0.00005188951,0.00001542869,0.0006834699],"genre_scores_gemma":[0.9989071,0.0001343675,0.0003895334,0.00002695114,0.000004759717,0.000005120701,0.00009341672,0.000003789194,0.0004349079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022558,"threshold_uncertainty_score":0.00342077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201957643104144,"score_gpt":0.2943166414139637,"score_spread":0.2741208771035493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}