{"id":"W2789624566","doi":"10.1124/dmd.117.079541","title":"Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity","year":2018,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Human Genome Research Institute; University of California, San Francisco; National Institutes of Health; American Foundation for Pharmaceutical Education; Amgen","keywords":"Biology; In vivo; Abcg2; Molecular biology; Cell culture; Luciferase; Transcription factor; Promoter; Kidney; Cancer research; Transporter; ATP-binding cassette transporter; Gene; Gene expression; Biochemistry; Transfection; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003501822,0.0001200012,0.0002158882,0.0001091594,0.00006846528,0.00002365493,0.00005840931,0.00006401989,0.00005982193],"category_scores_gemma":[0.000005865166,0.00007629929,0.00003988067,0.0002276816,0.00006267759,0.0001815215,0.000009846406,0.0001363368,0.000007209388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001138034,"about_ca_system_score_gemma":0.00001979682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001233578,"about_ca_topic_score_gemma":0.000318351,"domain_scores_codex":[0.999173,0.00007308434,0.0001489737,0.0002244066,0.0001809072,0.0001996268],"domain_scores_gemma":[0.999689,0.0000126995,0.00003520071,0.0001855275,0.00002727826,0.00005023909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004822996,0.003208936,0.03634798,0.0006972013,0.00009876277,0.0009435271,0.04532581,0.000009673577,0.8238013,0.02509521,0.0008198569,0.05882879],"study_design_scores_gemma":[0.002015062,0.0000402938,0.9650599,0.0001467012,0.00007824317,0.00002484072,0.0002738236,0.000463105,0.02837778,0.002190016,0.001190852,0.0001393631],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953904,0.0002628856,0.0004011462,0.001159743,0.0001797249,0.0004128005,0.00001837906,0.0000180448,0.002156868],"genre_scores_gemma":[0.9987999,0.00008216316,0.0001776168,0.0003867137,0.0001994732,0.00002722586,0.00001728288,0.00001044792,0.0002991532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.928712,"threshold_uncertainty_score":0.3111395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008214026595908027,"score_gpt":0.2401798040077125,"score_spread":0.2319657774118045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}