{"id":"W2789624566","doi":"10.1124/dmd.117.079541","title":"Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity","year":2018,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Human Genome Research Institute; University of California, San Francisco; National Institutes of Health; American Foundation for Pharmaceutical Education; Amgen","keywords":"Biology; In vivo; Abcg2; Molecular biology; Cell culture; Luciferase; Transcription factor; Promoter; Kidney; Cancer research; Transporter; ATP-binding cassette transporter; Gene; Gene expression; Biochemistry; Transfection; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002961807,0.0002799642,0.0003511444,0.0002999482,0.0001143556,0.000480542,0.0001523471,0.000362136,0.003270257],"category_scores_gemma":[0.0009188175,0.0001444909,0.0002755246,0.000265117,0.0002827715,0.0001581669,0.0001901298,0.0004758205,0.0004269014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629485,"about_ca_system_score_gemma":0.00009681444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005888559,"about_ca_topic_score_gemma":0.0004454487,"domain_scores_codex":[0.9996568,0.0001519682,0.00002636211,0.00006984773,0.00004850537,0.00004651393],"domain_scores_gemma":[0.9994554,0.0002522221,0.0001247681,0.00006395,0.00003562498,0.0000681269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001822312,0.0001056608,0.03891442,0.00004182241,0.0001567616,0.0008661138,0.0001290102,0.0004243927,0.9489893,0.0006158347,0.0003278125,0.007606516],"study_design_scores_gemma":[0.0003566795,0.001824296,0.3182146,0.00004593168,0.0006513592,0.0126468,0.0004170631,0.009078201,0.6463566,0.00169101,0.008653999,0.00006347646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974528,0.0003504253,0.001187756,0.0001154594,0.00001981575,0.000004291412,0.000268562,0.00004363323,0.0005571871],"genre_scores_gemma":[0.9990922,0.00007703454,0.0002423913,0.00003264944,0.00001077619,0.000003869477,0.0001857359,0.00003013944,0.0003252928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003270257,"threshold_uncertainty_score":0.01094013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008214026595908027,"score_gpt":0.2401798040077125,"score_spread":0.2319657774118045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}