{"id":"W2789626795","doi":"10.1016/s1470-2045(18)30143-8","title":"Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial","year":2018,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Musculoskeletal synovial abnormalities and treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer","keywords":"Pigmented villonodular synovitis; Medicine; Nilotinib; Clinical endpoint; Internal medicine; Synovitis; Surgery; Progressive disease; Adverse effect; Oncology; Dermatology; Clinical trial; Tyrosine kinase; Rheumatoid arthritis; Disease; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001335628,0.001595323,0.002530769,0.0003059825,0.0003367961,0.001332492,0.0006909855,0.001192523,0.003936321],"category_scores_gemma":[0.001050913,0.0003584936,0.001821434,0.0003062043,0.0009321594,0.001283368,0.0004233677,0.002455055,0.001013474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008467956,"about_ca_system_score_gemma":0.0008692113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005824929,"about_ca_topic_score_gemma":0.001946812,"domain_scores_codex":[0.9995389,0.0002221366,0.00002215205,0.00008174492,0.000032918,0.0001022038],"domain_scores_gemma":[0.999506,0.000117543,0.00009269323,0.00003503039,0.0000371549,0.0002114997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8887856,0.007939882,0.001701994,0.00270329,0.002822505,0.0002271343,0.000175598,0.001720182,0.01095723,0.0004204648,0.003547708,0.07899846],"study_design_scores_gemma":[0.8893014,0.102583,0.002858712,0.0001156276,0.0007826019,0.000245124,0.00009498194,0.0008993795,0.0007053329,0.0004545545,0.001919519,0.0000397227],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750198,0.01728096,0.0009779115,0.001204883,0.0004947845,0.001233627,0.0009969319,0.0001612852,0.002629771],"genre_scores_gemma":[0.9881368,0.004597649,0.001072158,0.001167824,0.0001901895,0.00112507,0.001087858,0.00002458714,0.002597834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003936321,"threshold_uncertainty_score":0.01316828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1019318549396969,"score_gpt":0.4160237556294407,"score_spread":0.3140919006897437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}