{"id":"W2789659032","doi":"10.1016/j.jpain.2017.12.215","title":"Mechanosensitive ion channels in articular nociceptors drive mechanical allodynia in osteoarthritis","year":2018,"lang":"en","type":"article","venue":"Journal of Pain","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Nociceptor; Mechanosensitive channels; Allodynia; Medicine; Osteoarthritis; Hyperalgesia; Nociception; Sensitization; PIEZO1; Anesthesia; Neuroscience; Ion channel; Internal medicine; Immunology; Receptor; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002548122,0.0001993519,0.0003478008,0.0003095917,0.0002908536,0.000614392,0.0003712946,0.0006265673,0.0007923322],"category_scores_gemma":[0.0003899494,0.0001976505,0.0002348423,0.0001523559,0.0005610147,0.0007063561,0.0003639835,0.000669855,0.0002060785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003971728,"about_ca_system_score_gemma":0.0002715955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007905305,"about_ca_topic_score_gemma":0.001003391,"domain_scores_codex":[0.9998653,0.00001563736,0.00001525996,0.00001677663,0.00004222082,0.00004477221],"domain_scores_gemma":[0.9998363,0.00002167504,0.00005489398,0.00001282569,0.00003097785,0.0000432687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008476435,0.00003263024,0.001888321,0.0000643033,0.00001036749,0.0003355115,0.00006270012,0.0001064512,0.9929162,0.0009128413,0.0001535613,0.002669477],"study_design_scores_gemma":[0.0002616032,0.0008672709,0.176737,0.00007949054,0.0001904932,0.004137824,0.0007949923,0.004939523,0.8017424,0.005423315,0.004769733,0.00005641531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868319,0.006519369,0.004234185,0.0008282182,0.00009783195,0.00001581936,0.0001228638,0.00008064108,0.001269218],"genre_scores_gemma":[0.9971331,0.001266156,0.0005416235,0.0001233881,0.00003836869,0.00001034909,0.00005781352,0.00001221656,0.0008168458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007923322,"threshold_uncertainty_score":0.002881706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007156511665797578,"score_gpt":0.2351264554751319,"score_spread":0.2279699438093343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}