{"id":"W2789675680","doi":"10.3389/fphar.2018.00092","title":"Scutellarin Increases Cisplatin-Induced Apoptosis and Autophagy to Overcome Cisplatin Resistance in Non-small Cell Lung Cancer via ERK/p53 and c-met/AKT Signaling Pathways","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Flavonoids in Medical Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation; National Natural Science Foundation of China; Science and Technology Planning Project of Guangdong Province; Guangdong Provincial Hospital of Traditional Chinese Medicine","keywords":"Cisplatin; Protein kinase B; Scutellarin; Apoptosis; Autophagy; MAPK/ERK pathway; Cancer research; Signal transduction; Lung cancer; Chemistry; PI3K/AKT/mTOR pathway; Medicine; Pharmacology; Oncology; Chemotherapy; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001211999,0.0003491694,0.0008257751,0.0007846166,0.0001344763,0.0000293261,0.0002846774,0.0003544681,0.0003594263],"category_scores_gemma":[0.0004566181,0.0003525974,0.000050758,0.0008172378,0.000381912,0.0001088497,0.0003517202,0.0009595171,0.000008837246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005194816,"about_ca_system_score_gemma":0.0003458817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007530766,"about_ca_topic_score_gemma":0.0003042935,"domain_scores_codex":[0.9967659,0.0003371563,0.0006444504,0.0008506838,0.0004463005,0.0009555594],"domain_scores_gemma":[0.9983193,0.0005115286,0.0001244235,0.0002743565,0.0001398712,0.000630546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001887407,0.0002835085,0.1442412,0.0006556427,0.0001142616,0.0002857042,0.002190401,0.00001966728,0.8195587,0.00001627048,0.01880093,0.0119463],"study_design_scores_gemma":[0.01485841,0.001474024,0.0705878,0.0009987974,0.000373966,0.00001627853,0.0006574393,0.02491972,0.8831689,0.0005566237,0.001456451,0.0009315601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910526,0.002630177,0.002339001,0.0005029007,0.001068045,0.001323376,0.00002200378,0.00004157408,0.001020279],"genre_scores_gemma":[0.9680543,0.000460558,0.02837955,0.0019055,0.0004647848,0.0002454873,0.000008915824,0.00005952769,0.000421409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07365344,"threshold_uncertainty_score":0.9998926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01788361701451919,"score_gpt":0.3248470718477049,"score_spread":0.3069634548331858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}