{"id":"W2789699314","doi":"10.1534/g3.118.200161","title":"Rapid Nuclear Exclusion of Hcm1 in Aging <i>Saccharomyces cerevisiae</i> Leads to Vacuolar Alkalization and Replicative Senescence","year":2018,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Vacuole; Saccharomyces cerevisiae; Autophagy; Yeast; Cell biology; Biology; Senescence; V-ATPase; Transcription factor; Ectopic expression; Biochemistry; Gene; Cytoplasm; Protein subunit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003266738,0.0002919492,0.0003140958,0.0001501816,0.0001455871,0.0000418468,0.0003950613,0.0001908244,0.00003555431],"category_scores_gemma":[0.0000176323,0.0003162831,0.00006539963,0.0002854644,0.0002194744,0.000008120124,0.0005246181,0.00007991374,0.000017539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000024958,"about_ca_system_score_gemma":0.00005911404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002633368,"about_ca_topic_score_gemma":0.00008246499,"domain_scores_codex":[0.9980511,0.0001130239,0.0004716924,0.0007464139,0.0002222251,0.0003955196],"domain_scores_gemma":[0.9986423,0.0000129834,0.0001956434,0.0007571734,0.0002343869,0.0001575131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003584216,0.00004556922,0.02156315,0.00007028691,0.00002202692,0.000001324631,0.001959315,0.000283287,0.8113766,0.00002876429,0.0001530848,0.1644607],"study_design_scores_gemma":[0.0006077027,0.001078728,0.009854647,0.00006189749,0.00005103775,0.00002772293,0.0004963432,0.0007963564,0.8358759,0.0001293388,0.1504279,0.000592418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8897094,0.1032895,0.005867487,0.0002535294,0.0001645574,0.0004559832,0.00002282289,0.00001933827,0.0002174086],"genre_scores_gemma":[0.9151197,0.07279577,0.0110208,0.0005235472,0.0003263963,0.00001164517,0.0000395163,0.00006214521,0.0001004751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1638683,"threshold_uncertainty_score":0.999929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183131288881646,"score_gpt":0.2472888519375306,"score_spread":0.2354575390487141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}