{"id":"W2789730857","doi":"10.1158/2159-8290.cd-17-0937","title":"Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":522,"is_retracted":false,"has_abstract":true,"ca_institutions":"Interior Health; BC Cancer Agency; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Astellas Pharma; Emil Aaltosen Säätiö; Prostate Cancer Canada; DOD Prostate Cancer Research Program; Terry Fox Research Institute; Movember Foundation; Prostate Cancer Foundation","keywords":"Enzalutamide; Prostate cancer; Abiraterone; Androgen receptor; Cancer; Liquid biopsy; Medicine; Oncology; Internal medicine; Circulating tumor cell; Cancer research; Biomarker; Cancer biomarkers; Exome sequencing; Gene; Biology; Mutation; Genetics; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004760381,0.0001705006,0.0003819741,0.0003453648,0.0001512613,0.000672647,0.0002239662,0.0004776221,0.00254317],"category_scores_gemma":[0.001883976,0.0001581214,0.0001639325,0.0005104231,0.0002254927,0.0002083581,0.0002009915,0.000823669,0.000325251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003653205,"about_ca_system_score_gemma":0.0002999779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008826067,"about_ca_topic_score_gemma":0.00140927,"domain_scores_codex":[0.9997323,0.00008221173,0.00001910699,0.00007588115,0.00006714284,0.0000233726],"domain_scores_gemma":[0.998791,0.0005414812,0.0002621209,0.00006499312,0.0001969438,0.0001434932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00919836,0.0003832285,0.6731809,0.0005671025,0.0005576484,0.0008047954,0.0002679702,0.001341215,0.06558029,0.0004755009,0.02451271,0.2231303],"study_design_scores_gemma":[0.0004424708,0.001972469,0.9662162,0.00009143292,0.0004124755,0.002077972,0.0002467138,0.003082577,0.01150556,0.001254403,0.01265497,0.00004281935],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711626,0.01360098,0.002322726,0.005644502,0.0005237317,0.00007349128,0.002790928,0.0002002077,0.003680892],"genre_scores_gemma":[0.9928105,0.002013944,0.0008079004,0.001546306,0.0004176035,0.00003638807,0.0007234151,0.00002673637,0.001617107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00254317,"threshold_uncertainty_score":0.008507788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801108254339182,"score_gpt":0.2996990652203911,"score_spread":0.2816879826769993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}