{"id":"W2789730857","doi":"10.1158/2159-8290.cd-17-0937","title":"Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":522,"is_retracted":false,"has_abstract":true,"ca_institutions":"Interior Health; BC Cancer Agency; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Astellas Pharma; Emil Aaltosen Säätiö; Prostate Cancer Canada; DOD Prostate Cancer Research Program; Terry Fox Research Institute; Movember Foundation; Prostate Cancer Foundation","keywords":"Enzalutamide; Prostate cancer; Abiraterone; Androgen receptor; Cancer; Liquid biopsy; Medicine; Oncology; Internal medicine; Circulating tumor cell; Cancer research; Biomarker; Cancer biomarkers; Exome sequencing; Gene; Biology; Mutation; Genetics; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000136571,0.0002229052,0.0003442725,0.0001388078,0.0001130461,0.00008406627,0.00007755506,0.00003931671,0.00005105582],"category_scores_gemma":[0.00001723905,0.0001649936,0.00002781958,0.0003967812,0.0002539523,0.0002829635,0.00007184925,0.0001981804,0.00001142453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008204933,"about_ca_system_score_gemma":0.0008316107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007967901,"about_ca_topic_score_gemma":0.0045598,"domain_scores_codex":[0.9984204,0.0000280169,0.0002478626,0.0005240918,0.0002496113,0.0005300092],"domain_scores_gemma":[0.9993083,0.00002840445,0.00008043363,0.0002651766,0.000115015,0.0002026976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01381918,0.0001910181,0.8164281,0.0009844726,0.0003659961,0.001355461,0.008995594,0.0004075936,0.14562,0.0001923903,0.001843143,0.009796992],"study_design_scores_gemma":[0.0125136,0.001362089,0.8857852,0.005473043,0.0002441366,0.00009567798,0.001347501,0.0003623674,0.07726351,0.0002727594,0.0142883,0.0009917725],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905329,0.005334952,0.00003481533,0.001679004,0.0001807196,0.0009708951,0.00009863913,0.00003182382,0.001136266],"genre_scores_gemma":[0.9889069,0.001131301,0.0002124109,0.000838414,0.0002701481,0.0004266819,0.00001325563,0.00005402733,0.008146919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06935712,"threshold_uncertainty_score":0.6728246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801108254339182,"score_gpt":0.2996990652203911,"score_spread":0.2816879826769993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}