{"id":"W2789775971","doi":"10.1016/j.nbd.2018.01.014","title":"Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice","year":2018,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; International Brain Research Organization; Michael Smith Health Research BC","keywords":"Minocycline; Dentate gyrus; FMR1; Fragile X syndrome; Neuroscience; NMDA receptor; Hippocampal formation; Synaptic plasticity; Psychology; Glutamate receptor; Neuroplasticity; Medicine; Psychiatry; Receptor; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631537,0.0007606445,0.0008827191,0.0005527984,0.0002711182,0.0004413903,0.0006162279,0.0006639624,0.001763691],"category_scores_gemma":[0.0001991786,0.0002907629,0.0003593339,0.0001544829,0.0004923464,0.0004483897,0.0002159931,0.001305428,0.000447783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005098082,"about_ca_system_score_gemma":0.0003727914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001709213,"about_ca_topic_score_gemma":0.004653802,"domain_scores_codex":[0.9997187,0.00001846616,0.00003270093,0.00007739443,0.00005724019,0.00009555533],"domain_scores_gemma":[0.9994416,0.00003162271,0.0002278645,0.00005150594,0.00003968034,0.0002076598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006567448,0.00009308166,0.0001703365,0.0000331609,0.000008575562,0.0000723756,0.00002063009,0.00003523493,0.9976088,0.00002978944,0.0000613009,0.001210074],"study_design_scores_gemma":[0.0000939478,0.001205082,0.007802791,0.0000175094,0.00005594418,0.000285362,0.0000807691,0.0003951346,0.9888208,0.00007439634,0.00115527,0.00001303605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996991,0.0007140406,0.0008745605,0.0001746704,0.00005607716,0.00001566521,0.0004290109,0.0002020626,0.0005428644],"genre_scores_gemma":[0.9921775,0.0007717519,0.001659895,0.00008626486,0.00002823846,0.00005503015,0.0004948637,0.0001037481,0.004622601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763691,"threshold_uncertainty_score":0.005900145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00639327813204799,"score_gpt":0.2252041975876963,"score_spread":0.2188109194556483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}