{"id":"W2789798757","doi":"10.1101/287839","title":"The Origins and Consequences of Localized and Global Somatic Hypermutation","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Prostate Cancer Canada; Canadian Institutes of Health Research; Government of Ontario; Ontario Institute for Cancer Research; Movember Foundation","keywords":"Somatic hypermutation; Point mutation; Mutation rate; Biology; Mutation; Genetics; Germline mutation; CDKN2A; Somatic cell; Gene; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00054626,0.0001611126,0.000301597,0.0008852476,0.0001694004,0.0004911115,0.0002055583,0.0002752744,0.001083558],"category_scores_gemma":[0.001196755,0.0001961998,0.0002739405,0.0005686355,0.000353433,0.0003380192,0.0005722182,0.0003518409,0.000208902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003972815,"about_ca_system_score_gemma":0.0001251654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007144834,"about_ca_topic_score_gemma":0.001459837,"domain_scores_codex":[0.9995352,0.00009058372,0.00002863153,0.0001470305,0.0001436516,0.00005490409],"domain_scores_gemma":[0.998782,0.000501083,0.0003718101,0.0001183888,0.00010771,0.0001189343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005828796,0.00004664938,0.3177413,0.0001836818,0.0002580866,0.0005266521,0.0001958644,0.00464118,0.6531919,0.0007426844,0.0002378387,0.02165131],"study_design_scores_gemma":[0.00001374119,0.0002699855,0.9089694,0.00001742297,0.00007597823,0.001201307,0.0002682193,0.01068788,0.07640705,0.000889201,0.001178247,0.00002152191],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965498,0.000382151,0.002122159,0.00001638128,0.00000319794,0.000009733768,0.0003519019,0.00006034565,0.0005041815],"genre_scores_gemma":[0.9988224,0.0001047829,0.0005714716,0.00001479767,0.000002135823,0.000006793674,0.0002833943,0.00001318797,0.0001809292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083558,"threshold_uncertainty_score":0.003624856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008980329279248382,"score_gpt":0.2319155470473219,"score_spread":0.2229352177680735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}