{"id":"W2789798757","doi":"10.1101/287839","title":"The Origins and Consequences of Localized and Global Somatic Hypermutation","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Prostate Cancer Canada; Canadian Institutes of Health Research; Government of Ontario; Ontario Institute for Cancer Research; Movember Foundation","keywords":"Somatic hypermutation; Point mutation; Mutation rate; Biology; Mutation; Genetics; Germline mutation; CDKN2A; Somatic cell; Gene; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335335,0.0002010653,0.0002127562,0.00002099958,0.0001148685,0.0001000017,0.000171689,0.000224541,0.000001778261],"category_scores_gemma":[0.0002557761,0.0001715704,0.00004140867,0.00006821346,0.0005764025,0.000002871069,0.0002944866,0.000084237,0.000001436426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000454247,"about_ca_system_score_gemma":0.0004357714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009130386,"about_ca_topic_score_gemma":0.00001909829,"domain_scores_codex":[0.9990126,0.00005046503,0.0002603246,0.0003873015,0.0001074894,0.0001818273],"domain_scores_gemma":[0.9989659,0.00004251195,0.0002317034,0.0004384845,0.0002283576,0.00009299452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007036005,0.00003044002,0.02141974,0.0002401489,0.0001662828,0.000004315383,0.000005558781,0.00001858636,0.975282,0.002475627,0.0002700508,0.00001695015],"study_design_scores_gemma":[0.00101222,0.0002859569,0.07153085,0.0002407954,0.000222392,1.923856e-7,0.00001310804,0.0003967979,0.9046154,0.0001776134,0.02085772,0.0006469713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992049,0.006226285,0.0006768337,0.0001503259,0.0003601135,0.0002710699,0.000245359,0.00001264793,0.000008320931],"genre_scores_gemma":[0.9940621,0.004094512,0.001501122,0.00008882059,0.0001969182,0.00003513875,6.189155e-7,0.00001979681,0.000001016751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07066654,"threshold_uncertainty_score":0.6996437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008980329279248382,"score_gpt":0.2319155470473219,"score_spread":0.2229352177680735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}