{"id":"W2789822035","doi":"10.1016/j.niox.2018.03.008","title":"Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets","year":2018,"lang":"en","type":"review","venue":"Nitric Oxide","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; Bundesministerium für Bildung und Forschung; Russian Foundation for Basic Research; Irish Research Council; Deutsche Forschungsgemeinschaft","keywords":"Prostacyclin; Riociguat; Platelet; cGMP-dependent protein kinase; Cell biology; Protein kinase A; Phosphorylation; Chemistry; Platelet activation; Iloprost; Kinase; Soluble guanylyl cyclase; PDE10A; Phosphodiesterase; Biology; Biochemistry; Receptor; Guanylate cyclase; Mitogen-activated protein kinase kinase; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000553939,0.0006308871,0.0008963943,0.001011931,0.0002117476,0.000719891,0.0006886612,0.0007871306,0.001170935],"category_scores_gemma":[0.0006312188,0.0002268419,0.0002511463,0.001129283,0.0005101774,0.0008144625,0.000600452,0.001362281,0.0005988468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004239494,"about_ca_system_score_gemma":0.001031437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008834448,"about_ca_topic_score_gemma":0.001415153,"domain_scores_codex":[0.9998653,0.00001876614,0.00002313491,0.00003054113,0.0000486454,0.00001358627],"domain_scores_gemma":[0.9997696,0.0001064729,0.00004136713,0.000007013702,0.00005203154,0.00002350236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001489976,0.00004986017,0.0002934038,0.01591738,0.00007740596,0.0003768188,0.0000593637,0.0003746981,0.005113778,0.005236965,0.01785599,0.9544953],"study_design_scores_gemma":[0.00003935357,0.0001558737,0.001954506,0.002972231,0.000206852,0.001977181,0.00008500995,0.0001785444,0.002449627,0.004613392,0.9853357,0.00003163144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001373721,0.9990595,0.00007556817,0.0001898289,0.0001546065,0.000001864887,0.00001060294,0.000002121758,0.0003685274],"genre_scores_gemma":[0.0008135028,0.9985195,0.00008960765,0.0001136064,0.0002043747,0.000002584171,0.00001611382,5.319887e-7,0.0002401877],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001170935,"threshold_uncertainty_score":0.003917158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01602021784962643,"score_gpt":0.2575598651995147,"score_spread":0.2415396473498883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}