{"id":"W2789854767","doi":"10.1038/s41434-018-0012-0","title":"AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy","year":2018,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Key Research and Development Program of China; Canadian Institutes of Health Research; Science and Technology Commission of Shanghai Municipality; Shanghai Municipal Education Commission","keywords":"Spiral ganglion; Cochlea; Synapse; Biology; Cell biology; Neuroscience; Ribbon synapse; Transgene; Hair cell; Neurotrophin-3; Gene; Neurotrophic factors; Brain-derived neurotrophic factor; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003903939,0.0004092295,0.0003444361,0.0001852527,0.0004369368,0.0001175973,0.0007453513,0.0002694964,0.0002688587],"category_scores_gemma":[0.0006480123,0.0003683559,0.0001079431,0.0006179026,0.000238838,0.0001492615,0.0002038862,0.000393106,0.001372742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009427313,"about_ca_system_score_gemma":0.0002149163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002996979,"about_ca_topic_score_gemma":0.000005725183,"domain_scores_codex":[0.9966854,0.0003774221,0.0004479716,0.0009348282,0.0006833095,0.0008710914],"domain_scores_gemma":[0.998041,0.0001662291,0.000237625,0.001085019,0.0001640768,0.0003060207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002156903,0.000108431,0.000189464,0.000009742256,0.000007517919,0.00002354241,0.0007657225,0.00001367945,0.987242,0.000027167,0.0004743898,0.01092258],"study_design_scores_gemma":[0.001396792,0.00073859,0.00304512,0.00006787961,0.000002859156,0.00001774585,0.00002744101,0.000988286,0.9818938,0.0001226908,0.01125558,0.0004431989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944479,0.0001221743,0.0002251803,0.0002933624,0.0006605447,0.001134299,0.00002165715,0.0004457323,0.002649089],"genre_scores_gemma":[0.9933102,0.0004299301,0.0006717144,0.004134825,0.0007740051,0.00008731442,0.000008610138,0.0001167534,0.0004666376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01078119,"threshold_uncertainty_score":0.9998769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05500224520509105,"score_gpt":0.2921151061936123,"score_spread":0.2371128609885212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}