{"id":"W2789854767","doi":"10.1038/s41434-018-0012-0","title":"AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy","year":2018,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Key Research and Development Program of China; Canadian Institutes of Health Research; Science and Technology Commission of Shanghai Municipality; Shanghai Municipal Education Commission","keywords":"Spiral ganglion; Cochlea; Synapse; Biology; Cell biology; Neuroscience; Ribbon synapse; Transgene; Hair cell; Neurotrophin-3; Gene; Neurotrophic factors; Brain-derived neurotrophic factor; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731072,0.0003458121,0.0003661004,0.0003033309,0.0001695586,0.0003068165,0.0002393715,0.0004574481,0.0008570905],"category_scores_gemma":[0.0001760062,0.0001686582,0.000289802,0.0001002916,0.000393754,0.0002729396,0.0002757846,0.0006121073,0.0002632152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218742,"about_ca_system_score_gemma":0.0003474816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000837295,"about_ca_topic_score_gemma":0.0009575913,"domain_scores_codex":[0.9998298,0.00001641365,0.00002497927,0.000040996,0.00004609647,0.00004167278],"domain_scores_gemma":[0.9998192,0.00003244996,0.00005054177,0.00002303948,0.00002185571,0.00005293132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003974916,0.00001381137,0.00003703383,0.00001125687,0.000001959843,0.00002797858,0.00001043543,0.00002271148,0.9994437,0.00004738886,0.000006786409,0.000337227],"study_design_scores_gemma":[0.00001809561,0.000414531,0.00189569,0.000007265191,0.00001946544,0.0002021473,0.00003404248,0.0007697909,0.9957183,0.00007277448,0.0008428211,0.000005164611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943638,0.0005882962,0.004093347,0.00006788702,0.000046709,0.00002586781,0.0001256847,0.0001145566,0.0005739827],"genre_scores_gemma":[0.9941379,0.0006211234,0.00263058,0.0000362973,0.00001092156,0.00003099424,0.0002050178,0.00002924747,0.002297917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008570905,"threshold_uncertainty_score":0.002867222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05500224520509105,"score_gpt":0.2921151061936123,"score_spread":0.2371128609885212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}