{"id":"W2789915698","doi":"10.1242/dev.159244","title":"Loss of <i>Mob1a/b</i> in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9","year":2018,"lang":"en","type":"article","venue":"Development","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Tokyo Medical and Dental University; Daiichi-Sankyo; Japan Agency for Medical Research and Development; Japan Society for the Promotion of Science; Smoking Research Foundation; Kyushu University; Ministry of Education, Culture, Sports, Science and Technology; Uehara Memorial Foundation","keywords":"Biology; Psychological repression; SOX9; YAP1; Transcription factor; Genetics; Cell biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003045273,0.001366894,0.0004644738,0.001870635,0.0005071283,0.0007056123,0.000716459,0.001113615,0.005997353],"category_scores_gemma":[0.0001784584,0.0007422454,0.000737501,0.0003489818,0.001116485,0.0003847347,0.0006930705,0.002021607,0.001966479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000634512,"about_ca_system_score_gemma":0.0003559498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445205,"about_ca_topic_score_gemma":0.002156726,"domain_scores_codex":[0.9993516,0.00007833181,0.0001058885,0.0001665877,0.0001647985,0.0001328009],"domain_scores_gemma":[0.9989526,0.00007217369,0.0004926934,0.00005341614,0.00004707234,0.0003820118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001064828,0.00003445221,0.0001273775,0.00002931281,0.000008476538,0.00009257406,0.0000151344,0.00003485407,0.9990609,0.000138464,0.00005208916,0.0002999285],"study_design_scores_gemma":[0.00007589052,0.0002792361,0.007387676,0.00003792557,0.0000507027,0.001091708,0.00009796867,0.001222939,0.9858388,0.0001125693,0.003785436,0.00001918786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810429,0.001192077,0.008119897,0.0004729158,0.0001199747,0.0001076729,0.004634873,0.0009799257,0.003329735],"genre_scores_gemma":[0.9669057,0.001085981,0.006284309,0.000236687,0.00005940129,0.0002504353,0.003089404,0.0007312876,0.02135688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005997353,"threshold_uncertainty_score":0.02006316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077554484924271,"score_gpt":0.2516292053142239,"score_spread":0.2408536604649812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}