{"id":"W2789917827","doi":"10.1002/9781118801512.ch8","title":"Plant Recombinant Lysosomal Enzymes as Replacement Therapeutics for Lysosomal Storage Diseases","year":2018,"lang":"en","type":"other","venue":"","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Enzyme replacement therapy; Recombinant DNA; Lysosome; Endocytosis; Alpha-galactosidase; Lysosomal storage disease; Lysosomal storage disorders; Enzyme; Glucuronidase; Biology; Intracellular; Biochemistry; Computational biology; Biotechnology; Medicine; Gene; Fabry disease; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851637,0.0004494371,0.0003151751,0.0005020734,0.000161562,0.0005223045,0.0003159359,0.0004549446,0.003001876],"category_scores_gemma":[0.0001418205,0.0001346511,0.0003228847,0.0004393774,0.0002402909,0.0004385072,0.0003761241,0.0007020382,0.002203956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004232607,"about_ca_system_score_gemma":0.0002094255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000310004,"about_ca_topic_score_gemma":0.0004381187,"domain_scores_codex":[0.9998558,0.00002109748,0.000008196957,0.00003025968,0.00006884061,0.00001579313],"domain_scores_gemma":[0.9999442,0.000009198515,0.00001603127,0.000009387715,0.00001141734,0.000009744974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001170962,0.00006161449,0.000106192,0.0004290309,0.000014749,0.0002212315,0.00004051064,0.0002384503,0.9607382,0.002522836,0.001439477,0.03407061],"study_design_scores_gemma":[0.00003168084,0.0002450798,0.0004934965,0.00004833331,0.0000372274,0.0007428023,0.00001980756,0.0007178518,0.8277351,0.0004640527,0.1694511,0.00001343743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.4925824,0.1707982,0.1864365,0.00288194,0.001180809,0.0007056421,0.004203335,0.005396409,0.1358147],"genre_scores_gemma":[0.7358891,0.07782287,0.07942786,0.0007838859,0.0001300291,0.0002666951,0.003763625,0.0007384926,0.1011775],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003001876,"threshold_uncertainty_score":0.01004225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531026395570147,"score_gpt":0.2700984203177108,"score_spread":0.2547881563620093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}