{"id":"W2789917827","doi":"10.1002/9781118801512.ch8","title":"Plant Recombinant Lysosomal Enzymes as Replacement Therapeutics for Lysosomal Storage Diseases","year":2018,"lang":"en","type":"other","venue":"","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Enzyme replacement therapy; Recombinant DNA; Lysosome; Endocytosis; Alpha-galactosidase; Lysosomal storage disease; Lysosomal storage disorders; Enzyme; Glucuronidase; Biology; Intracellular; Biochemistry; Computational biology; Biotechnology; Medicine; Gene; Fabry disease; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005148236,0.0003267759,0.0002585774,0.00005507626,0.00008995053,0.00003203853,0.0003030988,0.0003419984,0.001167223],"category_scores_gemma":[0.000007351853,0.0002627044,0.0001824147,0.0000356022,0.00008963234,0.000001199324,0.000057906,0.00005214627,0.0001159698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001298434,"about_ca_system_score_gemma":0.0001353922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004085479,"about_ca_topic_score_gemma":0.0001734892,"domain_scores_codex":[0.9987008,0.0000249786,0.0002237325,0.0005954355,0.0001335123,0.0003215156],"domain_scores_gemma":[0.9990849,0.00001521151,0.0001421655,0.000612901,0.00003179699,0.0001130397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002211021,0.000229001,0.0001264961,0.00005707219,0.0004190249,0.000001925954,0.000007752956,4.557635e-7,0.008877212,0.001873001,0.9873759,0.0008110544],"study_design_scores_gemma":[0.0007666709,0.0005050919,0.00007483748,0.000039784,0.0001670448,0.00001430715,0.00002218685,0.0000157618,0.01180138,0.00009525396,0.986106,0.0003917264],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.01170198,0.01787156,0.0308426,0.001696387,0.003743172,0.00775123,0.0199377,0.0007700523,0.9056853],"genre_scores_gemma":[0.01243118,0.001731158,0.001504041,0.0007167627,0.001179424,0.0003875885,0.005227815,0.0003674407,0.9764546],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.07076928,"threshold_uncertainty_score":0.9999825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531026395570147,"score_gpt":0.2700984203177108,"score_spread":0.2547881563620093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}