{"id":"W2789942404","doi":"10.1002/pep2.24058","title":"Unnatural amino acids improve affinity and modulate immunogenicity: Developing peptides to treat MHC type II autoimmune disorders","year":2018,"lang":"en","type":"article","venue":"Peptide Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"University of Windsor","keywords":"Immune system; Immunogenicity; Antigen; Immunology; Human leukocyte antigen; Major histocompatibility complex; Autoimmune disease; Biology; Chemistry; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478667,0.0003043741,0.0003152481,0.0002739164,0.00007898726,0.000306023,0.0002081134,0.0003650204,0.001205902],"category_scores_gemma":[0.0001212509,0.00009827317,0.0002369782,0.0002007561,0.0001327277,0.0003447383,0.0002032653,0.0006280617,0.0005533361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001638134,"about_ca_system_score_gemma":0.0001176519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543201,"about_ca_topic_score_gemma":0.0002359238,"domain_scores_codex":[0.999939,0.00001135595,0.000007078152,0.00001091702,0.00002164585,0.00001006511],"domain_scores_gemma":[0.9999671,0.000009100179,0.000007532883,0.00000167218,0.000009544312,0.00000503101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004626404,0.0002055705,0.0004165837,0.006659135,0.0001205827,0.0007052978,0.0001288366,0.001954915,0.6375139,0.006944658,0.006743982,0.3381438],"study_design_scores_gemma":[0.0001646203,0.002195165,0.002199596,0.0007651658,0.0002330762,0.002752187,0.00009660257,0.002171969,0.3061056,0.003007061,0.6802353,0.00007373166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0808349,0.8896571,0.01494923,0.0008501541,0.001055133,0.00009475768,0.0002841122,0.000207172,0.01206742],"genre_scores_gemma":[0.2738436,0.6981127,0.01461111,0.001476343,0.0004522969,0.0001432871,0.0005458287,0.00006014153,0.01075471],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001205902,"threshold_uncertainty_score":0.004034102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0233650555582772,"score_gpt":0.3225066562862007,"score_spread":0.2991416007279235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}