{"id":"W2789957933","doi":"10.1007/978-1-4939-7674-4_16","title":"Clinical Meaningfulness of Biomarker Endpoints in Alzheimer’s Disease Research","year":2018,"lang":"en","type":"book-chapter","venue":"Neuromethods","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Biomarker; Disease; Psychology; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.009138323,0.0003547501,0.0009870451,0.001455867,0.00006408382,0.00002572121,0.0003781149,0.0003974476,0.008124352],"category_scores_gemma":[0.002351006,0.0003175006,0.0004264958,0.0003190087,0.001218894,0.00006517238,0.0005462375,0.001634732,0.0003609451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005574673,"about_ca_system_score_gemma":0.0006329889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001176683,"about_ca_topic_score_gemma":0.000004686432,"domain_scores_codex":[0.9940488,0.001457603,0.001095896,0.0009837764,0.001762876,0.0006510873],"domain_scores_gemma":[0.9953873,0.001909188,0.0002184406,0.0009509259,0.0009154204,0.0006187259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.009423032,0.001966045,0.09614812,0.001165477,0.001311249,0.005698364,0.0001940922,6.357494e-8,0.001351911,0.006927673,0.02461283,0.8512011],"study_design_scores_gemma":[0.004944655,0.003898845,0.6495687,0.002700919,0.001030649,0.00005911733,0.00004573888,0.0001010927,0.001991718,0.03166797,0.3033056,0.0006849791],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.04497042,0.001523502,0.0002219822,0.0006020152,0.0007426305,0.002187784,0.00008815392,0.00005916447,0.9496043],"genre_scores_gemma":[0.2357405,0.002784411,0.01187773,0.001108503,0.001819322,0.0002670525,0.0002766338,0.00061789,0.7455079],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.8505161,"threshold_uncertainty_score":0.9999277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3694230069163694,"score_gpt":0.5372913736665292,"score_spread":0.1678683667501598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}