{"id":"W2789961905","doi":"10.1074/mcp.ra117.000447","title":"Promyelocytic Leukemia Protein (PML) Requirement for Interferon-induced Global Cellular SUMOylation","year":2018,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Agence Nationale de la Recherche","keywords":"SUMO protein; Promyelocytic leukemia protein; Biology; Gene isoform; Acute promyelocytic leukemia; Interferon; RNA splicing; Cell biology; Nuclear protein; Alternative splicing; Molecular biology; Ubiquitin; Cell culture; Gene; Genetics; Retinoic acid; Transcription factor; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004964235,0.0005152928,0.000346937,0.0000643007,0.000272038,0.00009604944,0.0006291919,0.0005216269,0.00003382288],"category_scores_gemma":[0.0001895846,0.0005550666,0.0003668526,0.000247259,0.0002070198,0.00001659311,0.0004213476,0.0001958344,0.00005729629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004595534,"about_ca_system_score_gemma":0.0006177987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003539167,"about_ca_topic_score_gemma":0.00002547611,"domain_scores_codex":[0.9969985,0.000191636,0.0005904519,0.001051343,0.0003920193,0.0007759796],"domain_scores_gemma":[0.9980065,0.000003524751,0.0003145012,0.001066826,0.00037478,0.0002338911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003573533,0.00008367262,0.0001309556,0.0001530215,0.00008554425,0.00000925252,0.00005443525,0.00002003807,0.9968284,0.0009609767,0.0001212575,0.001195091],"study_design_scores_gemma":[0.001634313,0.001485606,0.00003341606,0.000123035,0.00005619713,0.00001094543,0.00002585032,0.0009956595,0.9881062,0.001690991,0.005183638,0.0006541309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8726491,0.0001965395,0.1208773,0.0001197017,0.000392307,0.004577077,0.00005988435,0.00006564122,0.001062548],"genre_scores_gemma":[0.9798792,0.000002848735,0.01732314,0.0002503225,0.0006403992,0.0008927679,0.0002906628,0.000109074,0.0006115921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1072301,"threshold_uncertainty_score":0.9996901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887355511250047,"score_gpt":0.2564164491250365,"score_spread":0.2375428940125361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}