{"id":"W2790057655","doi":"10.1210/en.2017-03127","title":"SNAIL Mediates TGF-β1–Induced Downregulation of Pentraxin 3 Expression in Human Granulosa Cells","year":2018,"lang":"en","type":"article","venue":"Endocrinology","topic":"Biomarkers in Disease Mechanisms","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Science Foundation of Jiangsu Province; National Science Foundation","keywords":"Downregulation and upregulation; Gene knockdown; Biology; Snail; Granulosa cell; Transforming growth factor; SMAD; Internal medicine; Endocrinology; Cell biology; Cell culture; Follicular phase; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001398337,0.0001761664,0.0002694704,0.0001728919,0.000148311,0.0002289592,0.00008448751,0.0001421057,0.001927095],"category_scores_gemma":[0.00009427543,0.000135381,0.000324238,0.0001560993,0.0002269572,0.00009513391,0.0002075672,0.0004141274,0.0005655715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001831097,"about_ca_system_score_gemma":0.0002548074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009544338,"about_ca_topic_score_gemma":0.001359747,"domain_scores_codex":[0.9998881,0.00001740145,0.00001349224,0.00001898667,0.00002967409,0.0000323928],"domain_scores_gemma":[0.9999434,0.000008961804,0.00001481794,0.00001110515,0.000006849963,0.00001501803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002267659,0.0000321113,0.0004239464,0.00007325479,0.000006340771,0.0001137164,0.00004940263,0.00002854979,0.9979132,0.00005255839,0.0000741243,0.001006139],"study_design_scores_gemma":[0.00006994112,0.0004141948,0.01455342,0.00001362116,0.00002889789,0.0006497069,0.0001262278,0.0009159672,0.9771072,0.00006119876,0.006053928,0.000005723738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942474,0.002058985,0.001401593,0.0001272715,0.00003636873,0.00005991674,0.0005495192,0.00007478179,0.001444052],"genre_scores_gemma":[0.9928515,0.001651602,0.001326588,0.0001074115,0.00001233158,0.00006754315,0.001137735,0.00001442062,0.002830997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001927095,"threshold_uncertainty_score":0.006446838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477337090618025,"score_gpt":0.260130275999062,"score_spread":0.2453569050928817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}