{"id":"W2790100576","doi":"10.1128/aac.02618-17","title":"Understanding the Proline-Centric Design of a Peptide-Mediated Macrolide Resistance Mechanism","year":2018,"lang":"en","type":"letter","venue":"Antimicrobial Agents and Chemotherapy","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada; Government of Canada","keywords":"Mechanism (biology); Proline; Peptide; Computational biology; Macrolide Antibiotics; Mechanism of action; Biology; Chemistry; Microbiology; Biochemistry; Antibiotics; Amino acid; In vitro; Erythromycin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005020052,0.0003560729,0.0003718759,0.00009403401,0.0004209219,0.000824747,0.0007245509,0.002588377,0.001521691],"category_scores_gemma":[0.0007371496,0.0002085392,0.0002640266,0.0001017444,0.0007825777,0.001156816,0.0004851047,0.002831777,0.0009846771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007751213,"about_ca_system_score_gemma":0.0004889279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002121437,"about_ca_topic_score_gemma":0.0004322061,"domain_scores_codex":[0.9997984,0.0000447157,0.00002044616,0.00003641273,0.00005652923,0.0000435214],"domain_scores_gemma":[0.999773,0.00008428562,0.00004573427,0.00003311749,0.00003601685,0.00002786725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006993265,0.0002311172,0.0009544532,0.0008708709,0.00003733031,0.006586971,0.0003023151,0.006632396,0.8241405,0.06354921,0.02064324,0.07535222],"study_design_scores_gemma":[0.0002739845,0.00156813,0.0005718024,0.00009321905,0.00006590036,0.005480816,0.0002609817,0.02460558,0.6991948,0.03161595,0.2361968,0.00007193134],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5647486,0.04464579,0.1299932,0.1994362,0.008389828,0.0004975665,0.0007338753,0.0008790862,0.05067588],"genre_scores_gemma":[0.8786263,0.02160894,0.06112229,0.02456089,0.001593398,0.0002587758,0.0002883788,0.00008739996,0.01185352],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.002588377,"threshold_uncertainty_score":0.005623996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03237381803636907,"score_gpt":0.2350840547058794,"score_spread":0.2027102366695103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}