{"id":"W2790108630","doi":"10.1111/mmi.13911","title":"Negative supercoiling of DNA by gyrase is inhibited in <i>Salmonella enterica</i> serovar Typhimurium during adaptation to acid stress","year":2018,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Natural Sciences and Engineering Research Council of Canada; Biotechnology and Biological Sciences Research Council; Science Foundation Ireland","keywords":"DNA gyrase; DNA supercoil; Novobiocin; Biology; Salmonella enterica; DNA; Biochemistry; Nalidixic acid; Bacteria; Molecular biology; Microbiology; Escherichia coli; DNA replication; Gene; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166655,0.000266998,0.0002358388,0.0001213063,0.00007220248,0.0002463157,0.000125154,0.0001861629,0.0005395046],"category_scores_gemma":[0.0002092002,0.0001615777,0.000205715,0.00007045238,0.0001755476,0.0001025137,0.0001380897,0.0002857322,0.0002272081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001830001,"about_ca_system_score_gemma":0.0001214311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055035,"about_ca_topic_score_gemma":0.0008270639,"domain_scores_codex":[0.9998807,0.00002517411,0.00001121731,0.00002074534,0.00002217586,0.00003996634],"domain_scores_gemma":[0.9997675,0.00002606199,0.00009258521,0.00002102472,0.00003600645,0.00005688001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008892761,0.000006404821,0.0004779961,0.00001141457,0.000002810624,0.00001912621,0.00001311123,0.00001333483,0.9991586,0.000007556258,0.000009819129,0.0001907319],"study_design_scores_gemma":[0.0000140098,0.0008438422,0.05963899,0.00001107994,0.00002408881,0.0004382766,0.0001473461,0.0006479129,0.937127,0.0000307534,0.001066928,0.000009762235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990428,0.0002320795,0.0003302223,0.00002808215,0.000006804674,0.000003702358,0.0000841307,0.00001884661,0.0002533571],"genre_scores_gemma":[0.9988004,0.0001058721,0.0003256471,0.00002135596,0.000003506113,0.000005665964,0.0003139307,0.00001052228,0.000413053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055035,"threshold_uncertainty_score":0.002097845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004937337116907461,"score_gpt":0.221819501591839,"score_spread":0.2168821644749315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}