{"id":"W2790167050","doi":"10.1007/s12282-018-0848-6","title":"Cyclin-dependent kinase 4/6 inhibitors as first-line treatment for post-menopausal metastatic hormone receptor-positive breast cancer patients: a systematic review and meta-analysis of phase III randomized clinical trials","year":2018,"lang":"en","type":"review","venue":"Breast Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Metastatic breast cancer; Oncology; Meta-analysis; Internal medicine; Surgical oncology; Breast cancer; Randomized controlled trial; Hormone receptor; Clinical trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad","insufficient_payload"],"consensus_categories":["metaepi_narrow","metaepi_broad"],"category_scores_codex":[0.008802658,0.002145187,0.05386239,0.0009131357,0.0002032331,0.00006542118,0.0004175838,0.0004979909,0.002038764],"category_scores_gemma":[0.002149798,0.001219602,0.01087757,0.001400124,0.0007743857,0.0002668813,0.0001542902,0.0004835136,0.0000223987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001658302,"about_ca_system_score_gemma":0.001645814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001799563,"about_ca_topic_score_gemma":0.0002788895,"domain_scores_codex":[0.9803954,0.005471583,0.01007403,0.002003643,0.001193505,0.0008617935],"domain_scores_gemma":[0.9779494,0.006789682,0.01025246,0.001466128,0.002748454,0.0007938157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0523339,0.002452816,0.000001003077,0.2738718,0.5742741,0.00001524216,0.0001525096,0.000002445373,0.000002512162,0.00001175512,0.0001722834,0.09670964],"study_design_scores_gemma":[0.1217238,0.001681554,0.000002466206,0.06446388,0.805566,0.0001468578,0.00003376346,0.00001372192,0.000005206246,0.00001032848,0.005527967,0.0008244875],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000535341,0.8997993,0.0002690705,0.001295757,0.0003993207,0.03490573,0.0631998,0.0000700219,0.000007406556],"genre_scores_gemma":[0.0002958484,0.9577268,0.0003326501,0.0009753031,0.0006662539,0.03640195,0.002642861,0.0002769945,0.0006813633],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2312919,"threshold_uncertainty_score":0.9991289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1191923819866824,"score_gpt":0.468948783444096,"score_spread":0.3497564014574135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}