{"id":"W2790250024","doi":"10.1158/1538-7445.sabcs17-ot3-05-04","title":"Abstract OT3-05-04: A randomized, open-label, multi-center phase IV study evaluating palbociclib plus endocrine treatment versus a chemotherapy-based treatment strategy in patients with hormone receptor-positive, HER2-negative metastatic breast cancer in a real world setting (PADMA)","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Palbociclib; Internal medicine; Oncology; Metastatic breast cancer; Breast cancer; Population; Discontinuation; Chemotherapy; Randomization; Hazard ratio; Cancer; Randomized controlled trial; Progression-free survival; Surgery; Confidence interval","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002446258,0.001768442,0.002564678,0.0004634844,0.0005236404,0.001491884,0.001315224,0.002128532,0.01035173],"category_scores_gemma":[0.002081859,0.000630348,0.001903724,0.0004825695,0.001439392,0.001386656,0.0005770188,0.004482797,0.001426897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001012641,"about_ca_system_score_gemma":0.00196888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007592218,"about_ca_topic_score_gemma":0.001742517,"domain_scores_codex":[0.9992201,0.0004221156,0.00004687897,0.0001375679,0.00005548565,0.000117781],"domain_scores_gemma":[0.9985329,0.0003539843,0.0003229087,0.0001015645,0.00009827135,0.0005903112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9615387,0.02123121,0.0005717493,0.0006994318,0.0007417129,0.00003104244,0.0000363902,0.0002994425,0.002814053,0.0001193802,0.001053898,0.01086294],"study_design_scores_gemma":[0.9229239,0.07513686,0.0007790289,0.00002295389,0.0002433768,0.00001688025,0.00001195984,0.0002292763,0.0001820121,0.00008300212,0.0003631335,0.000007733864],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736857,0.003387364,0.001116874,0.001270537,0.0008152872,0.01408202,0.002418129,0.0002658226,0.002958388],"genre_scores_gemma":[0.9696236,0.001543283,0.003090566,0.002654356,0.0006836497,0.01576705,0.002035376,0.00003868481,0.004563408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035173,"threshold_uncertainty_score":0.03462994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1539898728747608,"score_gpt":0.4970297648779379,"score_spread":0.3430398920031771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}