{"id":"W2790267714","doi":"10.1021/acschembio.8b00072","title":"DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA","year":2018,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Mitochondrial DNA; DNA polymerase; Biology; Polymerase; DNA replication; Mutation; Mitochondrion; Human mitochondrial genetics; Genetics; Molecular biology; DNA polymerase II; Cell biology; DNA; Gene; Polymerase chain reaction; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002511049,0.0002546658,0.000205047,0.0002793894,0.00009850764,0.0004724609,0.0001353559,0.0002868297,0.002049969],"category_scores_gemma":[0.0004388694,0.0001453321,0.0001651612,0.0002003291,0.0002247663,0.0002434995,0.000210708,0.0004137592,0.0004140074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129525,"about_ca_system_score_gemma":0.0001255989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003608256,"about_ca_topic_score_gemma":0.0002783771,"domain_scores_codex":[0.999778,0.00005139539,0.00001938453,0.00007557211,0.00004081996,0.00003482318],"domain_scores_gemma":[0.9997396,0.00006214773,0.00008550718,0.00003120094,0.00003565653,0.00004599263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001228816,0.00002293562,0.00146895,0.00002835217,0.00001067301,0.00003711163,0.00001973503,0.00003671994,0.996626,0.00009443894,0.00003512205,0.001497051],"study_design_scores_gemma":[0.00001299942,0.000395684,0.009512061,0.000008821627,0.00002466428,0.0004580233,0.00006514273,0.0005093556,0.986418,0.00009637825,0.002493862,0.000004944328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952706,0.001574201,0.002183406,0.00009314901,0.00004388925,0.000008416832,0.0001096579,0.00005824304,0.0006584779],"genre_scores_gemma":[0.9968582,0.0007914384,0.0007822067,0.00003694286,0.00001193374,0.000008590188,0.0001907923,0.00001796414,0.001301903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049969,"threshold_uncertainty_score":0.006857872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099636344579311,"score_gpt":0.2713096496291375,"score_spread":0.2603132861833443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}