{"id":"W2790315963","doi":"10.1016/j.str.2018.02.007","title":"Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB","year":2018,"lang":"en","type":"article","venue":"Structure","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Biotechnology and Biological Sciences Research Council; Wellcome Trust; British Heart Foundation; Francis Crick Institute; Medical Research Council Canada; National Institutes of Health; Cancer Research UK","keywords":"Sigma factor; Bacillus subtilis; Dimer; Sigma; Chemistry; RNA polymerase; Zinc finger; Mutagenesis; Gene; Computational biology; Biology; Genetics; Biochemistry; RNA; Mutation; Bacteria; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001722787,0.0002092019,0.0001427884,0.00004895618,0.0001754843,0.00004067912,0.0001245602,0.0004969719,0.0002117318],"category_scores_gemma":[0.00003244752,0.0001661921,0.00004454742,0.0000854785,0.0003780802,0.000004723096,0.0001997409,0.0001391485,0.000004329491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001196332,"about_ca_system_score_gemma":0.00004893774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001862883,"about_ca_topic_score_gemma":0.0002876263,"domain_scores_codex":[0.9990501,0.00002585334,0.0001554443,0.0004394912,0.000107326,0.000221785],"domain_scores_gemma":[0.9994434,0.000003207127,0.00006053848,0.0002873693,0.000116202,0.00008928467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006574292,0.000003044229,0.0008680495,0.000008611574,0.00003340791,0.000001097539,0.0001004236,7.591735e-7,0.9902855,0.0001864358,0.000651671,0.007795289],"study_design_scores_gemma":[0.0005315341,0.0005100188,0.04456158,0.00000448739,0.00001204384,0.00003719491,0.00004432899,0.00002918419,0.8747459,0.002098159,0.07713895,0.0002865924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977353,0.0006788571,0.00006241964,0.0001756134,0.001041823,0.0001106953,0.00005973895,0.00002194701,0.0001135731],"genre_scores_gemma":[0.9971672,0.0000593708,0.000547102,0.0002307584,0.001651129,0.000002392244,0.0001648601,0.00001984167,0.0001572951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1155395,"threshold_uncertainty_score":0.6777117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006433236544349752,"score_gpt":0.2078264806797782,"score_spread":0.2013932441354284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}