{"id":"W2790315963","doi":"10.1016/j.str.2018.02.007","title":"Structural and Functional Insights into Bacillus subtilis Sigma Factor Inhibitor, CsfB","year":2018,"lang":"en","type":"article","venue":"Structure","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Biotechnology and Biological Sciences Research Council; Wellcome Trust; British Heart Foundation; Francis Crick Institute; Medical Research Council Canada; National Institutes of Health; Cancer Research UK","keywords":"Sigma factor; Bacillus subtilis; Dimer; Sigma; Chemistry; RNA polymerase; Zinc finger; Mutagenesis; Gene; Computational biology; Biology; Genetics; Biochemistry; RNA; Mutation; Bacteria; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160859,0.0002731596,0.0001644327,0.0001673191,0.0002822662,0.0003795354,0.000217254,0.0003375286,0.001778833],"category_scores_gemma":[0.0001507348,0.0001365007,0.0002177457,0.0001307845,0.0001853977,0.0002514508,0.0001522739,0.0008786479,0.0005913876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006258389,"about_ca_system_score_gemma":0.0006223043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003266516,"about_ca_topic_score_gemma":0.004065602,"domain_scores_codex":[0.99994,0.000009513928,0.000004386534,0.000007521402,0.00002656218,0.00001194007],"domain_scores_gemma":[0.9999312,0.00000916243,0.00001319419,0.000003642742,0.000009992727,0.00003267191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001886685,0.0000907533,0.0009711708,0.0001052689,0.00001145908,0.0003149423,0.00007676108,0.001024756,0.9871371,0.003215383,0.0006023492,0.006261524],"study_design_scores_gemma":[0.00006106766,0.0002654217,0.00436464,0.00004437533,0.00004414508,0.001288587,0.0002425045,0.009315682,0.921675,0.001312448,0.06135754,0.00002866964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.964904,0.00767928,0.01387246,0.001645528,0.0001782495,0.00004443798,0.00083912,0.0001586954,0.01067825],"genre_scores_gemma":[0.9705048,0.003718702,0.01718068,0.0003083595,0.00002913377,0.00002054115,0.00185734,0.00004299833,0.006337418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003266516,"threshold_uncertainty_score":0.006494999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006433236544349752,"score_gpt":0.2078264806797782,"score_spread":0.2013932441354284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}