{"id":"W2790350741","doi":"10.1093/jcag/gwy009.035","title":"A35 GENOME WIDE ASSOCIATION STUDY OF ABNORMAL INTESTINAL PERMEABILITY IN HEALTHY FIRST DEGREE RELATIVES OF CROHN’S PATIENTS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Public Health Ontario; Hospital for Sick Children; Université de Montréal; University of Alberta; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; McMaster University; University of Toronto","funders":"","keywords":"Single-nucleotide polymorphism; Genotyping; Imputation (statistics); Genome-wide association study; Minor allele frequency; Medicine; Cohort; Lactulose; Haplotype; Genotype; Internal medicine; Gastroenterology; Biology; Genetics; Gene; Missing data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006415448,0.0005209369,0.0008428796,0.000796138,0.001224759,0.0007367181,0.0003446024,0.000863991,0.00341089],"category_scores_gemma":[0.001854422,0.0004449791,0.0007926513,0.001278794,0.0002935105,0.0002695377,0.0003546828,0.0007045332,0.0003845926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003042044,"about_ca_system_score_gemma":0.0002549804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007289416,"about_ca_topic_score_gemma":0.00678936,"domain_scores_codex":[0.999109,0.000201196,0.00007101416,0.000404785,0.0001013702,0.0001126513],"domain_scores_gemma":[0.999097,0.0002210281,0.0002201897,0.0001636542,0.00009047935,0.0002075777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001892218,0.0001462402,0.9875877,0.00004099427,0.0006623334,0.001800686,0.0003413908,0.00009014445,0.003646891,0.0001027995,0.0006527503,0.003035837],"study_design_scores_gemma":[0.00007104917,0.0001790054,0.9973323,0.000007402187,0.0002351608,0.001028191,0.0001131458,0.0001994924,0.000156979,0.00006214851,0.0006063241,0.000008675947],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984956,0.000422098,0.0001358556,0.00007414359,0.00002251776,0.000006572307,0.0003150746,0.00001041593,0.0005178246],"genre_scores_gemma":[0.9993166,0.00007139762,0.0001287133,0.00002902358,0.00001335145,0.000004960895,0.0001684492,0.000004267514,0.0002634363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007289416,"threshold_uncertainty_score":0.01449394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008729223847579662,"score_gpt":0.2254242574960726,"score_spread":0.216695033648493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}