{"id":"W2790385254","doi":"10.1158/1538-7445.sabcs17-ot3-05-02","title":"Abstract OT3-05-02: BYLieve: A phase 2 study of alpelisib with fulvestrant or letrozole for treatment of <i>PIK3CA</i> mutant, hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2<i>–</i>) advanced breast cancer (aBC) progressing on/after cyclin-dependent kinase (CDK)4/6 inhibitor therapy","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Fulvestrant; Letrozole; Medicine; Aromatase inhibitor; Internal medicine; Oncology; Cancer; Metastatic breast cancer; Breast cancer; Estrogen receptor; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002688566,0.002123224,0.00225438,0.0005646005,0.0005534645,0.001630078,0.001649513,0.001911651,0.007536448],"category_scores_gemma":[0.001083718,0.0007331745,0.002053409,0.0005089791,0.001385388,0.001425095,0.0005496701,0.004051639,0.00161951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001138379,"about_ca_system_score_gemma":0.002593981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001827152,"about_ca_topic_score_gemma":0.004618431,"domain_scores_codex":[0.9991851,0.0004190529,0.00002785012,0.0001232385,0.00008501901,0.0001595901],"domain_scores_gemma":[0.9989813,0.0001454094,0.0001658091,0.00009960549,0.00009263433,0.0005151957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.780821,0.09631429,0.004582139,0.001180551,0.001620402,0.0002241087,0.0003812969,0.001044981,0.05125979,0.0005319822,0.007185001,0.05485459],"study_design_scores_gemma":[0.6248104,0.3607239,0.005906162,0.00004883289,0.0005261801,0.0002666428,0.00008009215,0.0005025503,0.002820904,0.0002021904,0.00407993,0.0000323057],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829974,0.002244335,0.0007374357,0.0007235749,0.0002006567,0.005539472,0.003950706,0.0001779384,0.00342852],"genre_scores_gemma":[0.9562014,0.003688165,0.004382821,0.002557923,0.0004195972,0.009061645,0.01405496,0.0001451889,0.009488285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007536448,"threshold_uncertainty_score":0.02521193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06258979464817743,"score_gpt":0.4222820193877104,"score_spread":0.359692224739533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}