{"id":"W2790423711","doi":"10.1080/19336896.2018.1443000","title":"Design, implementation, and interpretation of amplification studies for prion detection","year":2018,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases","keywords":"Disease; Computational biology; Prion protein; Biology; Medicine; Neuroscience; Bioinformatics; Virology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001755279,0.00005326848,0.00005755795,0.0000292697,0.0000729247,0.000008872071,0.0000318087,0.00003480155,0.00000261047],"category_scores_gemma":[0.00007651283,0.00005183366,0.0000222432,0.00003530253,0.00004013357,0.000006674674,0.00002496841,0.00001081162,6.673827e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001043057,"about_ca_system_score_gemma":0.00001551296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003995248,"about_ca_topic_score_gemma":0.00001571332,"domain_scores_codex":[0.9995729,0.00003524505,0.0001385318,0.0001456445,0.00004290766,0.00006478489],"domain_scores_gemma":[0.999581,0.00001570849,0.0001046898,0.00008494711,0.0001955257,0.00001807775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001547781,0.000005535013,0.0001292599,0.00002821219,0.00001958884,4.652686e-9,0.0001618951,0.000004518831,0.6211895,0.00003260292,0.00006203281,0.3782121],"study_design_scores_gemma":[0.0003618425,0.0005747934,0.002059477,0.00001607145,0.0000256842,0.000001027687,0.0004018813,0.001109792,0.9923573,0.0008942254,0.002130267,0.00006765374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4927061,0.002911314,0.5039302,0.00003673007,0.00006155798,0.0003417403,0.000003347776,0.000005482487,0.000003579649],"genre_scores_gemma":[0.993525,0.001532014,0.004694909,0.00003685263,0.00009358786,0.00007072163,0.0000346565,0.000006595872,0.000005686764],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5008189,"threshold_uncertainty_score":0.2113715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03310272994659177,"score_gpt":0.3658255600996175,"score_spread":0.3327228301530257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}