{"id":"W2790423711","doi":"10.1080/19336896.2018.1443000","title":"Design, implementation, and interpretation of amplification studies for prion detection","year":2018,"lang":"en","type":"article","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases","keywords":"Disease; Computational biology; Prion protein; Biology; Medicine; Neuroscience; Bioinformatics; Virology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03122397,0.002216658,0.001457013,0.001948041,0.00169128,0.002529113,0.002781806,0.002114607,0.003888092],"category_scores_gemma":[0.0227883,0.001873439,0.001119414,0.0008632997,0.002933092,0.001525284,0.002278945,0.002631639,0.00310401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001276605,"about_ca_system_score_gemma":0.004970035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007862962,"about_ca_topic_score_gemma":0.00135288,"domain_scores_codex":[0.9749219,0.0100478,0.002839597,0.00399521,0.006886712,0.00130881],"domain_scores_gemma":[0.9794497,0.004647379,0.002829466,0.006446186,0.005786429,0.0008407995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001945014,0.0009930406,0.004680161,0.0007234293,0.00008450341,0.0003032536,0.0009038345,0.003219996,0.9118318,0.006836638,0.0008932637,0.06758515],"study_design_scores_gemma":[0.0004418561,0.008094981,0.006119761,0.0001455742,0.0001639876,0.0004580384,0.0002786866,0.01334567,0.9432402,0.004955917,0.02251872,0.0002365645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.03301918,0.000254695,0.9389378,0.0002101025,0.0002048602,0.02304741,0.0005874797,0.001931026,0.001807305],"genre_scores_gemma":[0.07125559,0.0003219697,0.901943,0.0002727484,0.00006757933,0.02345982,0.0006910428,0.0003262105,0.001662042],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03122397,"threshold_uncertainty_score":0.1651301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03310272994659177,"score_gpt":0.3658255600996175,"score_spread":0.3327228301530257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}