{"id":"W2790448745","doi":"10.1016/j.cell.2018.02.048","title":"B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; Deutsche Forschungsgemeinschaft; Wellcome Trust; H2020 European Research Council; Howard Hughes Medical Institute; Dr. Ralph and Marian Falk Medical Research Trust; California Institute for Regenerative Medicine; Cancer Research Institute","keywords":"Biology; Pentose phosphate pathway; Protein phosphatase 2; Glycolysis; Transcription factor; Psychological repression; B cell; Cell growth; Cell biology; Cell; Phosphatase; Biochemistry; Enzyme; Phosphorylation; Genetics; Gene expression; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007813115,0.0001267966,0.0001549902,0.0004219428,0.0001385323,0.0003746122,0.0001515334,0.0002174725,0.00108862],"category_scores_gemma":[0.00009174133,0.0001097296,0.0001104496,0.0003482181,0.000151972,0.0002156981,0.0002468289,0.0002764796,0.0001782174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187746,"about_ca_system_score_gemma":0.00007137918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004136596,"about_ca_topic_score_gemma":0.0002996346,"domain_scores_codex":[0.999938,0.000009175879,0.000003747648,0.00001433961,0.00001199584,0.00002272077],"domain_scores_gemma":[0.9999448,0.000006555392,0.00001692966,0.00000740218,0.000006779421,0.00001747971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004561734,0.00001765929,0.01548501,0.00002003072,0.00002345694,0.0002987569,0.00004696855,0.00006524054,0.9793553,0.0003010083,0.0001014518,0.003828984],"study_design_scores_gemma":[0.00003406373,0.0005396742,0.5727847,0.00001283415,0.00009085108,0.008323289,0.0005860389,0.001397769,0.4106582,0.001399981,0.004154389,0.00001821682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979531,0.0006232437,0.0006355209,0.00005382371,0.00000431637,0.000002897385,0.0001613305,0.00002343892,0.0005423047],"genre_scores_gemma":[0.9990971,0.0002837519,0.0001840147,0.0000233259,0.00000479193,0.000003701281,0.0001821276,0.000006629602,0.0002146141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00108862,"threshold_uncertainty_score":0.003641784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801396201009867,"score_gpt":0.2435917876533536,"score_spread":0.225577825643255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}